A0A7D3NWN7 · A0A7D3NWN7_ADEC2

Function

function

Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

1905100200300400500600700800900
TypeIDPosition(s)Description
Site729Involved in interaction with pre-protein VI

GO annotations

AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell nucleus
Cellular ComponentT=25 icosahedral viral capsid
Molecular Functionstructural molecule activity
Biological Processmicrotubule-dependent intracellular transport of viral material towards nucleus
Biological Processsymbiont entry into host cell

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hexon protein
  • Short names
    CP-H
  • Alternative names
    • Protein II

Gene names

    • Name
      L3

Organism names

Accessions

  • Primary accession
    A0A7D3NWN7

Subcellular Location

Host nucleus
Virion
Note: Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers.

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed; by host
Modified residue2N-acetylalanine; by host
ChainPRO_50285490742-905Hexon protein
Modified residue893Phosphotyrosine; by host

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Homotrimer. Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet. Interacts with the hexon-interlacing protein; this interaction lashes the hexons together. Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid. Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-587Adenovirus Pll hexon N-terminal
Domain588-809Adenovirus Pll hexon C-terminal

Sequence similarities

Belongs to the adenoviridae hexon protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    905
  • Mass (Da)
    101,114
  • Last updated
    2020-12-02 v1
  • Checksum
    CAD317399AE50038
MATPSMLPQWSYMHIAGQDAAEYLSPALVQFAQATSSYFKLDNKFRNPTVAPTHDVTTERSQRLQLRFVPVMQEDGQYTYKTRFQLAVGDNRVLDMASTYFDIRGTLDRGPSFKPYSGTAYNALAPKAGANNCLFNGQGANINTLAQVPSAGAITVNGQAAVTNNTYQPEPQLGPESWVDGSLAELGGASGRALKASTPRMPCYGSYAPPTNENGGQATGPVESRFYKVTTNNNNEADAMLYTEDVNLQAPDTHLVHQVPEGQVTGVQGLGQQAAPNRPNYIGFRDNFIGLMYYNSNGNLGVLAGQSSQLNAVVDLQDRNTELSYQLLLDALTDRSRYFSMWNQAVDSYDQDVRIIDNHGVEDDMPNYCYPLSGMGPLTNMTTMKVNNQNFQAENANVGPIQKIGFGNVEAMEINLNANLFKSFLYSNVALYLPDAFKYTPENIVAPANANTYAYMNVRLPAANLIDTFVNIGARWSPDVMDTVNPFNHHRNAGLRYRSQLLGNGRYCSFHIQVPQKFFAIKNLLLLPGTYTYEWSFRKDVNMILQSSLGNDLRVDGATINIQSINLYASFFPMAHNTASTLEAMLRNDVNDQSFADYLSSANMLYPIPANTTNLPISIPARNWAGFRGWSFTRIKQRETPALGSPYDPYFTYSGSIPYLDATFYLSHTFRRVSIMFDSSVSWPGNDRLLTPNEFEIKRYVDGEGYNVAQSNMTKDWFMVQMLAHYNIGYQGYHLPESYKDRMYSFLRNFEPMCRQLVDVANYAAYQPVTVGHQHNNSGYASALSAFNPREGHPYPANWPYPLIGANAVPTVTQKKFLCDRSLWRIPFSSNFMSMGTLTDLGQNLLYSNSAHALDMTFEVDAMNEPTLLYVLFEVFDVARVHQPHRGVIEVVYLRTPFSAGNATT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN402908
EMBL· GenBank· DDBJ
QJI08265.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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