A0A7C9HDE9 · A0A7C9HDE9_9BACT

  • Protein
    Bifunctional protein FolD
  • Gene
    folD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site166-168NADP+ (UniProtKB | ChEBI)
Binding site194NADP+ (UniProtKB | ChEBI)
Binding site235NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      F0475_03455

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • A2879
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Prevotellaceae > Prevotella

Accessions

  • Primary accession
    A0A7C9HDE9

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-121Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain124-290Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    294
  • Mass (Da)
    31,959
  • Last updated
    2021-02-10 v1
  • Checksum
    2C56F169CFDE1F99
MEYQLIDGKATATAIKQQIAEEVKAITKAGGKQPHLVAILVGHDGGSETYVKNKVIACEQCGFKSTLIRYETDVTEEELLTCVDKLNKDDDVDGFIVQLPLPKHIDEQKIIMAIDYRKDVDGFHPVNVGRMAIGLPCFISATPLGILTLLQHYHIPTSGKKCVILGRSNIVGKPMAQLMMQKQYGDATVTICHSHSATLKKECQEADIIIAAIGRPDFLTADMVKPGAVVIDVGTTRVPDATRKSGYRLNGDVKFDEVAPLCSFITPVPGGVGPMTICSLMKNTLAAGKKEYYK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VVIQ01000003
EMBL· GenBank· DDBJ
MUL27383.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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