A0A7C6K5Y9 · A0A7C6K5Y9_9FIRM

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site119Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site120Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site155substrate
Binding site181substrate
Site191-192Cleavage; by autolysis
Active site192Nucleophile
Binding site192substrate
Binding site278substrate
Binding site400substrate
Binding site405substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Molecular Functionmethione N-acyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      GXX59_00260

Organism names

Accessions

  • Primary accession
    A0A7C6K5Y9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50285417081-191Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5028541707192-405Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    405
  • Mass (Da)
    42,696
  • Last updated
    2020-12-02 v1
  • Checksum
    0DD1B663E4CB7721
MSQQLKYKEISGGVTTPQGFLAAGVTAGVRKNRQRDVALLYSEIPATAAAVYTQNQVKAAPVLVTQEHLSGGSAQAVVVNSGIANACTGEQGLTDARMMAKLAGDALEIPVEHVAVASTGVIGEYLPMERIQSGIKEAARLLSTEGGAAAEAILTTDTVTKEYAIQFNLGGREVKVGGMAKGSGMIHPNMATMLAFITTDACVEQQALKLALCWAVDRSFNNITVDGDTSTNDMVVTLANGQAGNPLISADQPEFNLFREAVYIVCVELAKMIARDGEGASKLLEVQVKNAASEKEARIIARSIASSSLVKTAVFGEDTNWGRVLSAAGACGVVFDPNMVDVYLGDILVAAEGRGLPFDEKRADAILQESDVTITVDLHKGTATGIAWGCDLTFDYIKINADYRT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DUMY01000010
EMBL· GenBank· DDBJ
HHV34006.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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