A0A7C4Y522 · A0A7C4Y522_9BACT

Function

function

Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
    EC:2.7.13.3 (UniProtKB | ENZYME | Rhea)

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Molecular Functionphosphorelay sensor kinase activity
Molecular Functionprotein dimerization activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxygen sensor histidine kinase NreB
  • EC number
  • Alternative names
    • Nitrogen regulation protein B

Gene names

    • ORF names
      ENR39_00070

Organism names

Accessions

  • Primary accession
    A0A7C4Y522

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Cytoplasm

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-185Histidine kinase

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    187
  • Mass (Da)
    20,760
  • Last updated
    2020-12-02 v1
  • Checksum
    0AD9F1B79F2B755D
KQIMAASLMSLGFAKDSMKENPAVAVETIENVRDYIREAIQELRRLSHQLAPSADTNLPLAEKIRMLADNMNSAKSLDIHINVDDFDEPLHNDIQLAFYRILQEQLSNILKYAKATIAEIIIERADKNVMLTIRDNGKGFDTSVKKDGIGLENIKRRVNVIGGEAKIISSPGKGCSVVLKVPFGKDN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DSQV01000004
EMBL· GenBank· DDBJ
HGW83320.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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