A0A7C4WGK4 · A0A7C4WGK4_9ARCH

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site7-12substrate
Binding site36Mg2+ (UniProtKB | ChEBI)
Active site65Proton acceptor
Binding site65Mg2+ (UniProtKB | ChEBI)
Binding site66substrate
Binding site141-144substrate
Binding site165substrate
Binding site170-171substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      ENU85_03650

Organism names

Accessions

  • Primary accession
    A0A7C4WGK4

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    196
  • Mass (Da)
    22,129
  • Last updated
    2020-12-02 v1
  • Checksum
    CEE1C9AD260BDDC2
MRFTLATTNKGKIKEFEAIFKQFNLKYRVELLKTKEIQSMDLREIARESVIYAYSMLREPVLVEDAGLFIRALNGFPGPYSSYVYKTIGVTGVLKLMSNITDRSAVFRSVIAFYSPYTGIKLFSGEAGGEISYEPRGTSGFGFDPIFIPEEGDGRTFAEIEVYEKNKISHRGKAAMKFIEWINGLKTLPPPYASVE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DTEC01000128
EMBL· GenBank· DDBJ
HGU73309.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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