A0A7C4PLQ9 · A0A7C4PLQ9_9CHLR

  • Protein
    Multifunctional fusion protein
  • Gene
    aroB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 divalent metal cation per subunit. Can use either Co2+ or Zn2+.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site49-54ATP (UniProtKB | ChEBI)
Binding site53Mg2+ (UniProtKB | ChEBI)
Binding site71substrate
Binding site95substrate
Binding site117substrate
Binding site156ATP (UniProtKB | ChEBI)
Binding site176substrate
Binding site310-314NAD+ (UniProtKB | ChEBI)
Binding site334-335NAD+ (UniProtKB | ChEBI)
Binding site347NAD+ (UniProtKB | ChEBI)
Binding site356NAD+ (UniProtKB | ChEBI)
Binding site374-377NAD+ (UniProtKB | ChEBI)
Binding site389Zn2+ (UniProtKB | ChEBI)
Binding site448Zn2+ (UniProtKB | ChEBI)
Binding site464Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-dehydroquinate synthase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionmagnesium ion binding
Molecular Functionshikimate kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    Shikimate kinase
  • EC number
  • Short names
    SK
  • Recommended name
    3-dehydroquinate synthase
  • EC number
  • Short names
    DHQS

Gene names

    • Name
      aroB
    • Synonyms
      aroK
    • ORF names
      ENT37_11965

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SpSt-573
  • Taxonomic lineage
    Bacteria > Chloroflexota > Anaerolineae > Anaerolineales > Anaerolineaceae > Anaerolinea

Accessions

  • Primary accession
    A0A7C4PLQ9

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-159AAA+ ATPase

Sequence similarities

Belongs to the shikimate kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    557
  • Mass (Da)
    59,539
  • Last updated
    2020-12-02 v1
  • Checksum
    3BE6C12EF5E4DE63
MKCAPVLTHCAGRAWTTYTWTVNLIFFGPSETMIASKSETLYFIYGPPGSGKSTLARRLAGLLDLPFMDLDEQIQASAGMPIPAIFDREGERGFRQRERVALEAALQSGRGVVALGGGALLDPTSRSLVESAGRVLCLRAERETLFERLGQEVGTRPLLGEDAGWRERLDALLAVRAAQYHSFPLSLDTSALNPEEAARQAQLKFGAWRVSGMGAAYDVRVVQGGLDALGSMLRARGLEGPLALVSDSQVAPLYAEKVEAALKAAGYAVQRVVIPAGEEHKTLETVSHLWEAFLAARLDRRSTVLALGGGVVGDLAGFAAAVYLRGVRWVALPTTLLAMADASLGGKTGADLPQGKNLIGAFHPPALVLSDPATLSTLPEAELRSGMAEVVQHGQLADQALFARAEGGWEAMRANLDETVRRAMAVKIAFIQADPYEKNIRAALNLGHTVGHAVEVASGYRLRHGEAVAIGLRVEARLAEALGVAEAGLSGRIEACLRGLGLPTRIPEEIDREGFLRALRVDKKNAAGQVRFALPERVGAYRVGVTVEMDFSELLTI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DSYK01000593
EMBL· GenBank· DDBJ
HGS22564.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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