A0A7C4NT33 · A0A7C4NT33_9BACT

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site106Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site107Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site143substrate
Binding site166substrate
Site176-177Cleavage; by autolysis
Active site177Nucleophile
Binding site177substrate
Binding site256substrate
Binding site377substrate
Binding site382substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetyl-CoA:L-glutamate N-acetyltransferase activity
Molecular Functionglutamate N-acetyltransferase activity
Molecular Functionmethione N-acyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      ENT66_03190

Organism names

  • Taxonomic identifier
  • Strain
    • SpSt-6
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Thermodesulfobacteria > Thermodesulfobacteriales > Thermodesulfobacteriaceae > Thermodesulfobacterium

Accessions

  • Primary accession
    A0A7C4NT33

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50285413311-176Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5028541332177-382Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    382
  • Mass (Da)
    42,364
  • Last updated
    2020-12-02 v1
  • Checksum
    F689690EB2843B29
MFVPEGFLFSGISCGIKKEDKLDLGLIYSPEELTAWGVFTTNTVKAVPVLLGKRFIKEKKIHGILANSGVANACTGEEGFKRALTILKEVAKYLKIPYKSLLPASTGVIGEQLPLEKILPNIPNLISNLSVQNYIQFAKAIMTTDTFPKIISKKTEDGIVIFGVAKGAGMIAPNMATMLAFILTDAEVSKDYLKKSLPKIVEQSFNRITVDGDTSTNDTVYMLCSNLKKIKNWEKFESLCLEVAKELAYLIIKDGEGTSKVIKILIKGAKTKNEAKILATSVANSPLVKTAFYGGDPNWGRIFSALGKSGIKFNPQEIEIYLNGIPWVANFKSINNEAKIKEEMRKPEIELCIRLKLGKMSYEMLTTDLTEEYIRINAHYRT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DSZN01000059
EMBL· GenBank· DDBJ
HGQ85381.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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