A0A7C3L2K4 · A0A7C3L2K4_9ARCH

Function

function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
    EC:6.5.1.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

156350100150200250300350400450500550
Type
IDPosition(s)Description
Binding site247ATP (UniProtKB | ChEBI)
Active site249N6-AMP-lysine intermediate
Binding site254ATP (UniProtKB | ChEBI)
Binding site269ATP (UniProtKB | ChEBI)
Binding site299ATP (UniProtKB | ChEBI)
Binding site340ATP (UniProtKB | ChEBI)
Binding site416ATP (UniProtKB | ChEBI)
Binding site422ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA ligase (ATP) activity
Molecular Functionmetal ion binding
Biological Processcell division
Biological ProcessDNA biosynthetic process
Biological ProcessDNA ligation
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological Processlagging strand elongation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA ligase
  • EC number
  • Alternative names
    • Polydeoxyribonucleotide synthase [ATP]

Gene names

    • Name
      lig
    • ORF names
      ENR43_02235

Organism names

  • Taxonomic identifier
  • Strain
    • SpSt-4
  • Taxonomic lineage
    Archaea > Nanoarchaeota > Candidatus Nanoarchaeia > Nanoarchaeales > Nanopusillaceae

Accessions

  • Primary accession
    A0A7C3L2K4

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain328-457ATP-dependent DNA ligase family profile

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    563
  • Mass (Da)
    64,737
  • Last updated
    2020-12-02 v1
  • Checksum
    6DF7028052032200
MEFVKLAQLYKKLESVTEKTAKASLLAKFIKEIPDNLLEKTCLLILGTVFFPWEEKKIGVGEKLTIRAIATATGFPKERVEKLFVQYGDLGQVTEELTKQKKQKSLFKKTLTVEEIYNTLREIGELEGEGAIEKKVRLLANLLIHAEPIEAKYIVRTVLEDLRIGVGEGIMIEAIAEAYGLPAEDVEYAYSILHNFGKLISIIRKEGKQAITEIKPEVGIPIRVMLAVKAENVMEAFEIVGRPAEIEYKYDGFRVQIHKKENEIWLWTRRLENVTKQFPDVIEYIKECLPDKDFIVEGEIVGYDKNTNKFLPFQKISQRIKRKYDIEKMVKEIPVELHLFDIIYYDNELLLNKSFKERRQILEKIVKEKGGKVLLAKAIITSSDEEAERFFKEAVEKGLEGIVFKNLNAPYRPGRRIGYMVKLKPTKETLDVVIVAAEWGEGKRAGWLTSFTVAVRDPDSGKYLEIGEVGTGIKEKKESPEDITFEELTKLLEPLIIKQEGKKVYIKPAIVIEVQYDEIQKSPKYSSGFALRFPRLVRLRPDRSPEDIDTIERVTELYERQKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DSQZ01000034
EMBL· GenBank· DDBJ
HFP18303.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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