A0A718PRP1 · A0A718PRP1_SALTS

Function

function

Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site119Important for catalytic activity
Site139Important for catalytic activity
Binding site296substrate
Binding site324NAD+ (UniProtKB | ChEBI)
Binding site343NAD+ (UniProtKB | ChEBI)
Binding site400-402NAD+ (UniProtKB | ChEBI)
Binding site407NAD+ (UniProtKB | ChEBI)
Binding site429NAD+ (UniProtKB | ChEBI)
Active site450For 3-hydroxyacyl-CoA dehydrogenase activity
Binding site453NAD+ (UniProtKB | ChEBI)
Binding site500substrate
Binding site660substrate

GO annotations

AspectTerm
Cellular Componentfatty acid beta-oxidation multienzyme complex
Molecular Function3-hydroxyacyl-CoA dehydrogenase activity
Molecular Function3-hydroxybutyryl-CoA epimerase activity
Molecular Functiondelta(3)-delta(2)-enoyl-CoA isomerase activity
Molecular Functionenoyl-CoA hydratase activity
Molecular FunctionNAD+ binding
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fatty acid oxidation complex subunit alpha

Including 2 domains:

  • Recommended name
    Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase
  • EC number
  • Recommended name
    3-hydroxyacyl-CoA dehydrogenase
  • EC number

Gene names

    • Name
      fadB
    • ORF names
      G1W59_20550
      , G1W72_21595
      , G1W73_20510
      , G1W84_21305
      , G1W85_21320
      , G1X00_17495
      , G1X11_17550
      , G1X12_16765
      , G1X18_17505
      , G1X31_17075
      , G1X46_17500
      , G1X98_21890

Organism names

Accessions

  • Primary accession
    A0A718PRP1

Interaction

Subunit

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-189Enoyl-CoA hydratase/isomerase
Region311-7293-hydroxyacyl-CoA dehydrogenase
Domain316-4943-hydroxyacyl-CoA dehydrogenase NAD binding
Domain496-5923-hydroxyacyl-CoA dehydrogenase C-terminal
Domain627-6913-hydroxyacyl-CoA dehydrogenase C-terminal
Region707-729Disordered

Sequence similarities

In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    729
  • Mass (Da)
    79,642
  • Last updated
    2020-12-02 v1
  • Checksum
    C34C68ECFF35713C
MLYKGDTLYLDWLEDGIAELVFDAPGSVNKLDTATVASLGQALEVLEKQHDLKGLLLRSNKAAFIVGADITEFLSLFLVPEEQLSQWLHFANSVFNRLEDLPVPTLAAVNGYALGGGCECVLATDYRLATPDLRIGLPETKLGIMPGFGGSVRLPRMLGADSALEIIAAGKDVGAEHALKIGLVDGVVKQEKLIEGAIAVLRQAITGDLDWRAKRQPKLEPLKLSKIEAAMSFTIAKGMVAQTAGKHYPAPMTAVKTIEAAARFGREEALNLENKSFVPLAHTNEARALVGIFLNDQYVKGKAKKLTKDIETPKQAAVLGAGIMGGGIAYQSAWKGVPVIMKDINDKSLNLGMTEAAKLLNKQLERGKIDGLKLAGVISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPETVLASNTSTIPIGELASALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNNCPGFFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPQRMQKEYRDAIDALFDASRFGQKNGLGFWRYKEDSKGKPKKEEDAAVDDLLASVSQTKRDFSDDEIIARMMIPMINEVVRCLEEGIIASPAEADMALVYGLGFPPFHGGAFRWLDTQGSAKYLDMAQQYQHLGPLYEVPEGLRDKTRHNEPYYPPVEPARPVGSLKTA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DAAPKI010000031
EMBL· GenBank· DDBJ
HAD6547180.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPKM010000032
EMBL· GenBank· DDBJ
HAD6565932.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPKX010000030
EMBL· GenBank· DDBJ
HAD6619004.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPLF010000027
EMBL· GenBank· DDBJ
HAD6662004.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPLM010000027
EMBL· GenBank· DDBJ
HAD6689931.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPLX010000018
EMBL· GenBank· DDBJ
HAD6745591.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPMU010000019
EMBL· GenBank· DDBJ
HAD6858982.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPMY010000018
EMBL· GenBank· DDBJ
HAD6868187.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPNB010000018
EMBL· GenBank· DDBJ
HAD6882881.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPNA010000019
EMBL· GenBank· DDBJ
HAD6892359.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPNO010000018
EMBL· GenBank· DDBJ
HAD7090039.1
EMBL· GenBank· DDBJ
Genomic DNA
DAAPPM010000029
EMBL· GenBank· DDBJ
HAD7252163.1
EMBL· GenBank· DDBJ
Genomic DNA

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