A0A6V8SL91 · A0A6V8SL91_9CLOT

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1836100200300400500600700800
TypeIDPosition(s)Description
Binding site85ATP (UniProtKB | ChEBI)
Binding site103-107ATP (UniProtKB | ChEBI)
Binding site492ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      bsdtw1_03440

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • TW1
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium

Accessions

  • Primary accession
    A0A6V8SL91

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-570SecA family profile
Domain87-246Helicase ATP-binding
Domain414-586Helicase C-terminal

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    836
  • Mass (Da)
    95,413
  • Last updated
    2020-12-02 v1
  • Checksum
    D1BCD7C0406DB213
MGILTKVFGSYSEREVKRIIPIVDKIETFDSAMQALTDEQLRGKTEEFKNRYKNGESLDSLLPEAFAVVREASYRLHSEKHYREQLIGGIVLHQGRISEMKTGEGKTLCATLPAYLNAISGKGVHIVTVNDYLARRDMEWMGEIYQFLGLTTGVILHDLDNDQRRAAYNADITYGTNNEFGFDYLRDNMVIYKEEKVQRELSFAIVDEVDSILIDEARTPLIISGAGEKSTDFYKIADFFVKRLFKEKHFTVDEKAHSVMLTEDGIKEAELAFGVENYADAENMELQHHITQALKANYLMRLDKDYMVKDGEVIIVDEFTGRLMEGRRYSDGLHQAIEAKEGVKVERESKTLATITFQNYFRMYKKLSGMTGTALTEENEFREIYGLDVIVIPTHKPIKRSDNPDVVYKTVAGKFNAIAEEIQETNKTGQPILVGTTSIEKSEALSALLKRKGVKHQVLNAKYHEQEAEIVTHAGEKGMVTIATNMAGRGTDIKLGEGVVELGGLKIIGTERHESRRIDNQLRGRSGRQGDPGTSRFYISLEDDLMRIFGSDRLQGVVEKLGLSDDDAIESKMVSKSIENAQKKVEGNNFDVRKTLLGYDDVMNKQREVIYKQRAQVLEGETLRQQVQDMIKEVVYASVDSHISGEEETFDDEVKQLISYMEDLYIPQGMFEPKDLEVLSNDEMKEKLLNLAKDIYREKEEHFGEEQMREVERVILLRVVDTKWMDHIDNMDHLKQGIGLRAYKQQDPVQAYQFEGSNMFDEMIENIKVDTVKLLFHVQMEHTPERERVVEETTTNLVDDSIKKQPTKKEAKVGRNDLCPCGSGKKYKNCCGREVV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BLZR01000001
EMBL· GenBank· DDBJ
GFP77322.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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