A0A6T7WCG8 · A0A6T7WCG8_9EUKA

  • Protein
    Delta-aminolevulinic acid dehydratase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Features

Showing features for active site.

137650100150200250300350
TypeIDPosition(s)Description
Active site242Schiff-base intermediate with substrate
Active site295Schiff-base intermediate with substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionmetal ion binding
Molecular Functionporphobilinogen synthase activity
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-aminolevulinic acid dehydratase
  • EC number

Gene names

    • ORF names
      CPOL0286_LOCUS785
      , CPOL0286_LOCUS786

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UIO037
  • Taxonomic lineage
    Eukaryota > Haptista > Haptophyta > Prymnesiophyceae > Prymnesiales > Prymnesiaceae > Prymnesium

Accessions

  • Primary accession
    A0A6T7WCG8

Interaction

Subunit

Homooctamer.

Family & Domains

Sequence similarities

Belongs to the ALAD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    376
  • Mass (Da)
    41,137
  • Last updated
    2020-12-02 v1
  • Checksum
    64ED3D07C47D6D6C
AFVGAPAGAPAQRARAGAAMVIAPFDGESLVSVPDGVLKTNQLGLPWVDQRARPRRNRKSEAVRRMVRENSLSPADFIYPLFIHDEDSNVLIASMPGCERHSLASMVAEAKDAWQYGVRSFVVFPKVDDALKSNRGEEAYNPDGIVPRAVAMLKDALPDSIVCTDVALDPYSSKGHDGIVEDGKIVNDRTIEQLCKQSVMQAKAGSDIVAPSDMMDGRVGAIRDALDSEGFTEVSILAYTAKYASAYYGPFRDALDSHPGFGDKKTYQQDPANGREALIEARLDEFEGADMLMVKPGLPYLDVICRLRQESSLPIAAYHVSGEYSMLKAAHERGWLDERKVALETLMCFKRAGADVILTYYAKQASKWLLEDAGNL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HBKO01001573
EMBL· GenBank· DDBJ
CAE2195432.1
EMBL· GenBank· DDBJ
Transcribed RNA
HBKO01001574
EMBL· GenBank· DDBJ
CAE2195433.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

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