Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A6S6TGP1 · A0A6S6TGP1_9BACT

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13substrate
Active site69Proton acceptor
Binding site69Mg2+ (UniProtKB | ChEBI)
Binding site70substrate
Binding site149-152substrate
Binding site172substrate
Binding site177-178substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      HELGO_WM16402

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HLG_WM_MAG_10
  • Taxonomic lineage
    Bacteria > Bacteroidota > Saprospiria > Saprospirales > Saprospiraceae > Aureispira > environmental samples

Accessions

  • Primary accession
    A0A6S6TGP1

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    192
  • Mass (Da)
    21,466
  • Last updated
    2020-12-02 v1
  • MD5 Checksum
    09CAFA8967D2FB86BF83EDB62054437C
MSKLVFATANKNKVSEIQKIMGTQYDFLSLEDIGCTEDIPETQPTIIGNALQKARYVYKNYGINCFSEDTGLLVEALDGAPGVYSARYAGPARDANDNMDKLLKELEHKENRTAQFKTVIALILDGKEYTFEGVVEGEILKKRQGTAGFGYDPIFKPKESKQTFAQMSSQEKGIISHRGRATQKLRNFLLNL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CACVAQ010000218
EMBL· GenBank· DDBJ
CAA6814532.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help