A0A6S6RSH8 · A0A6S6RSH8_9GAMM

Function

function

Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 2 Zn2+ or Co2+ ions per subunit.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site66Zn2+ 1 (UniProtKB | ChEBI)
Active site68
Binding site100Zn2+ 2 (UniProtKB | ChEBI)
Binding site100Zn2+ 1 (UniProtKB | ChEBI)
Active site134Proton acceptor
Binding site135Zn2+ 2 (UniProtKB | ChEBI)
Binding site163Zn2+ 1 (UniProtKB | ChEBI)
Binding site353Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncobalt ion binding
Molecular Functionsuccinyl-diaminopimelate desuccinylase activity
Molecular Functionzinc ion binding
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinyl-diaminopimelate desuccinylase
  • EC number
  • Short names
    SDAP desuccinylase
  • Alternative names
    • N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase

Gene names

    • Name
      dapE
    • ORF names
      SISI_0239

Organism names

  • Taxonomic identifier
  • Strain
    • SiSi
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Zymobacter group > Candidatus Portiera

Accessions

  • Primary accession
    A0A6S6RSH8

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain176-275Peptidase M20 dimerisation

Sequence similarities

Belongs to the peptidase M20A family. DapE subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    393
  • Mass (Da)
    44,784
  • Last updated
    2020-12-02 v1
  • Checksum
    8211DBDA751D3C20
MYYLLNLVFNLLSKKSITPKDNECQFLIGCILSKFGFEIDVLNKKGVYNLWASKGFGKTTLLFVGHTDVVPSGTIKEWKHPPFIPFLNNKGYIISRGIVDMKGSLCAMIKATCNLIKIYPKYKGKISFLITSDEEGEGKYGTNYVINKIIKRKEIINSCIIGEPTSKIFVGDTLKIGRRGSLNAKIIVYGIQSHIAYTKTLLNPIHILINLTHYLLKIKWDKGNKYFSKTSFQISNFNAGLGVTNMLPNYAKLLCNFRFSNELTANEIKNKVSNIFLLFNLENNKDYKIEWYISGEPYITNKGKLLNAVTFGIKYICKLLPQINTNGGISDGRFIKKTCNQIIELGLKNDTIHKINECVFFSDIILLTKVYQIIIEYLFIYQKTKWSQGDLNS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CACTJB010000002
EMBL· GenBank· DDBJ
CAA3708736.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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