A0A6S6M5J5 · A0A6S6M5J5_9BACT

Function

function

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site, active site.

132150100150200250300
TypeIDPosition(s)Description
Binding site20-22FMN (UniProtKB | ChEBI)
Binding site74FMN (UniProtKB | ChEBI)
Active site103Proton donor
Binding site142FMN (UniProtKB | ChEBI)
Binding site172FMN (UniProtKB | ChEBI)
Binding site227-228FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionRNA binding
Molecular FunctiontRNA dihydrouridine synthase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-dihydrouridine synthase
  • EC number

Gene names

    • ORF names
      GEOBRER4_n1474

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R4
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfuromonadia > Geobacterales > Geobacteraceae > Citrifermentans

Accessions

  • Primary accession
    A0A6S6M5J5

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-311DUS-like FMN-binding

Sequence similarities

Belongs to the dus family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    321
  • Mass (Da)
    34,817
  • Last updated
    2020-12-02 v1
  • Checksum
    22C8D6519723EFA3
MQKTVALGPLVLKNQLFLAPMAGITNLPMRIISREGGASFAFTEMVSVNGLTREGRKSFDLLQSSAEDRPIGMQLFGDDPEMLAEAARLVEEYGELIDINMGCPVRKVVGTGAGSALMKDPLKVGRIVRSVRKATKLPLTIKIRTGWVCGDDTFMEVGRIAQEEGCDAVTLHPRSRAQMFEGKADWSRIGELKSALSIPVIGSGDLFSAADAVGMLTQTGCDAVMVARGAMGNPWIFREALSLLAGEEPVPPTVKERLAVSRRHLELFTEFAGGRVALMEMRKHLSWYSKGLPGAAQFRAAVNRIESTAELIGAMEEFFDA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023213
EMBL· GenBank· DDBJ
BCG46665.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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