A0A6S6M500 · A0A6S6M500_9BACT

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.

Features

Showing features for binding site.

149050100150200250300350400450
TypeIDPosition(s)Description
Binding site218Mg2+ 2 (UniProtKB | ChEBI)
Binding site218Mg2+ 1 (UniProtKB | ChEBI)
Binding site222Mg2+ 1 (UniProtKB | ChEBI)
Binding site279substrate
Binding site389Mg2+ 2 (UniProtKB | ChEBI)
Binding site393Mg2+ 2 (UniProtKB | ChEBI)
Binding site414substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular Functionisomerase activity
Molecular Functionketol-acid reductoisomerase activity
Molecular Functionmetal ion binding
Biological Processisoleucine biosynthetic process
Biological Processvaline biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ketol-acid reductoisomerase
  • EC number

Gene names

    • ORF names
      GEOBRER4_n1530

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R4
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfuromonadia > Geobacterales > Geobacteraceae > Citrifermentans

Accessions

  • Primary accession
    A0A6S6M500

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-209KARI N-terminal Rossmann
Domain210-343KARI C-terminal knotted
Domain345-486KARI C-terminal knotted

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    490
  • Mass (Da)
    54,019
  • Last updated
    2020-12-02 v1
  • Checksum
    DBF1B5DE8C2120C2
MGENYFNTLPLRRQLQELGTCRFMEASEFANGCEYVKGKKIVIVGCGAQGLNQGLNMRDSGLDVSYTLRKEAIEQKRQSYLNASENGFKVGSYEELLPTADIVMNLAPDKQHSNVVATVIPFMKQGAVFSYAHGFNIVEEGTQIRKDLTVIMVAPKCPGSEVRAEYKRGFGVPTLIAVHGENDPNSDGLEIAKAIASAQGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGALLCFDKMTQNGIDAPYAVKLIQYGWETITEALKHGGITNMMDRLSNPAKLVAFKLADELKDIMRPLFQKHMDDIMSGEFSRTMMEDWANDDVKLLTWREQTGQTAFEKTEAAGEISEQEYFDKAILMVAMVKAGVELAFETMVQTGIEPESAYYESLHETPLIANTIARKKLYEMNRVISDTAEYGCYLFSHACVPLLKDFMSKVGTDVIGKGLSVNDNSVDNQLLVAVNAEIRSHLVEEVGAELRAAMKGMQKIV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023213
EMBL· GenBank· DDBJ
BCG46721.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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