A0A6S6M500 · A0A6S6M500_9BACT
- ProteinKetol-acid reductoisomerase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids490 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Cofactor
Pathway
Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.
Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 218 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 218 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 222 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 279 | substrate | ||||
Sequence: S | ||||||
Binding site | 389 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 393 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 414 | substrate | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | isomerase activity | |
Molecular Function | ketol-acid reductoisomerase activity | |
Molecular Function | metal ion binding | |
Biological Process | isoleucine biosynthetic process | |
Biological Process | valine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKetol-acid reductoisomerase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfuromonadia > Geobacterales > Geobacteraceae > Citrifermentans
Accessions
- Primary accessionA0A6S6M500
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-209 | KARI N-terminal Rossmann | ||||
Sequence: LQELGTCRFMEASEFANGCEYVKGKKIVIVGCGAQGLNQGLNMRDSGLDVSYTLRKEAIEQKRQSYLNASENGFKVGSYEELLPTADIVMNLAPDKQHSNVVATVIPFMKQGAVFSYAHGFNIVEEGTQIRKDLTVIMVAPKCPGSEVRAEYKRGFGVPTLIAVHGENDPNSDGLEIAKAIASAQGGDRAGVLES | ||||||
Domain | 210-343 | KARI C-terminal knotted | ||||
Sequence: SFVAEVKSDLMGEQTILCGMLQAGALLCFDKMTQNGIDAPYAVKLIQYGWETITEALKHGGITNMMDRLSNPAKLVAFKLADELKDIMRPLFQKHMDDIMSGEFSRTMMEDWANDDVKLLTWREQTGQTAFEKT | ||||||
Domain | 345-486 | KARI C-terminal knotted | ||||
Sequence: AAGEISEQEYFDKAILMVAMVKAGVELAFETMVQTGIEPESAYYESLHETPLIANTIARKKLYEMNRVISDTAEYGCYLFSHACVPLLKDFMSKVGTDVIGKGLSVNDNSVDNQLLVAVNAEIRSHLVEEVGAELRAAMKGM |
Sequence similarities
Belongs to the ketol-acid reductoisomerase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length490
- Mass (Da)54,019
- Last updated2020-12-02 v1
- ChecksumDBF1B5DE8C2120C2
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP023213 EMBL· GenBank· DDBJ | BCG46721.1 EMBL· GenBank· DDBJ | Genomic DNA |