A0A6S6M369 · A0A6S6M369_9BACT

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

116420406080100120140160
TypeIDPosition(s)Description
Active site119
Active site137

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      GEOBRER4_n3697

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • R4
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfuromonadia > Geobacterales > Geobacteraceae > Citrifermentans

Accessions

  • Primary accession
    A0A6S6M369

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane65-83Helical
Transmembrane95-112Helical
Transmembrane132-153Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    164
  • Mass (Da)
    18,319
  • Last updated
    2020-12-02 v1
  • Checksum
    702C49543E4E6070
MKAKYIILLAVSTLVLVLDQLTKVYIDKTMRLHDSIPVIDGFFSITYLRNKGAAFGILANSAWRLPFFLLVSAVAVLVILVVLSRLRDDQKGSAVSLSLIFSGALGNLIDRVRLGEVIDFLDVYWKGHHWPAFNVADSAICVGVFLLAIEMVLEERREKAQKQD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023213
EMBL· GenBank· DDBJ
BCG48802.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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