A0A6S6M337 · A0A6S6M337_9BACT
- ProteinAdenosylhomocysteinase
- GeneahcY
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids465 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Catalytic activity
- H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine
Cofactor
Note: Binds 1 NAD+ per subunit.
Pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 56 | substrate | ||||
Sequence: T | ||||||
Binding site | 131 | substrate | ||||
Sequence: D | ||||||
Binding site | 191 | substrate | ||||
Sequence: E | ||||||
Binding site | 192-194 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: TTT | ||||||
Binding site | 221 | substrate | ||||
Sequence: K | ||||||
Binding site | 225 | substrate | ||||
Sequence: D | ||||||
Binding site | 226 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 255-260 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GYGDVG | ||||||
Binding site | 257-262 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: GDVGKG | ||||||
Binding site | 278 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 313 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 334-336 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: IGH | ||||||
Binding site | 379 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 386 | NAD+ (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | adenosylhomocysteinase activity | |
Biological Process | L-homocysteine biosynthetic process | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylhomocysteinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Desulfuromonadia > Geobacterales > Geobacteraceae > Citrifermentans
Accessions
- Primary accessionA0A6S6M337
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 226-385 | S-adenosyl-L-homocysteine hydrolase NAD binding | ||||
Sequence: NIYGCRESLMDGIKRATDVMVAGKVAVICGYGDVGKGCAQAMRGLQAQVWVTEVDPICALQAAMEGYKVVTMEWAADKADIFVTTTGNIDVITHDHMKAMKHNAIVCNIGHFDNEIEVAKLKQYQWENIKPQVDHVIFPDGKRIILLAEGRLVNLGCATG |
Sequence similarities
Belongs to the adenosylhomocysteinase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length465
- Mass (Da)51,292
- Last updated2020-12-02 v1
- Checksum81D16F5A47C1C6EA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP023213 EMBL· GenBank· DDBJ | BCG48030.1 EMBL· GenBank· DDBJ | Genomic DNA |