A0A6S6G4F7 · A0A6S6G4F7_9SPHN

  • Protein
    UvrABC system protein A
  • Gene
    uvrA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for binding site.

110031002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site32-39ATP (UniProtKB | ChEBI)
Binding site701-708ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentexcinuclease repair complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionexcinuclease ABC activity
Molecular Functionzinc ion binding
Biological Processnucleotide-excision repair
Biological ProcessSOS response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    UvrABC system protein A
  • Short names
    UvrA protein
  • Alternative names
    • Excinuclease ABC subunit A

Gene names

    • Name
      uvrA
    • ORF names
      HMP06_3216

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HMP6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingomonas

Accessions

  • Primary accession
    A0A6S6G4F7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Forms a heterotetramer with UvrB during the search for lesions.

Family & Domains

Features

Showing features for region, domain, zinc finger.

TypeIDPosition(s)Description
Region268-294Disordered
Domain376-655ABC transporter
Domain665-997ABC transporter
Zinc finger800-826C4-type

Sequence similarities

Belongs to the ABC transporter superfamily. UvrA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,003
  • Mass (Da)
    108,742
  • Last updated
    2021-04-07 v1
  • Checksum
    4AC857EF73CF2469
MLTHISVRGAREHNLKDVSVDIPRDTLTVITGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLELMQKPDVDHIEGLSPAISIEQKTTSRNPRSTVATVTEIYDYMRLLWARVGIPYSPATGLPISAQTVSQMVDRVMALPEGTRLYLLAPVVRARKGEYRKELLEWQKAGFTRVRIDGEIYEIDEAPALDKKLKHDVEVVVDRLVVGPDMATRLAESFEAALKLAEGLAYVDLVDGTVAEALSAPLPLAGGAGGGAVREIPQSFQADMPSPSPSREREGSLGGAPEQKMKGAGIPANRIVFSEKFACPVSGFTIAEIEPRLFSFNAPQGACPACDGLGEKLLFDEDLVVPNHALSIKKGAVVPWAKSNPPSPYYMQVLGSLAREFGFSLETPWEDLPGEVQLIILHGTGGKPVTLTFIDGKKSYDVKKPFEGVIGNLNRRMLSTESAWMREELSKYQSSAPCEVCGGARLKPEALAVKIGMRDISSVTRLSVVDALTWFESVPADLSTQQNAIAERILKEILERLGFLNNVGLDYLNLDRTSGTLSGGESQRIRLASQIGSGLSGVLYVLDEPSIGLHQRDNDMLLKTLRRLRDLGNTVLVVEHDEDAIRTADYVIDMGPGAGVHGGHIVAQGTFEEVLANENSITADYLSGRREVAVPKTRRKGNGKKLTVHNATANNLKGVTASLPLGTFTCITGVSGSGKSSFTIDTLYAAAARSLNGARVLAGKHDKVTGLQYLDKVIDIDQSPIGRTPRSNPATYTGAFTQIRDWFAGLPESQARGYKPGRFSFNVKGGRCEACQGDGLLKIEMHFLPDVYVTCDVCHGARYNRETLEVKFKGLSIADVLDMTVEDAVEFFKAVPPIRDKMAMLAEVGLGYVKVGQQATTLSGGEAQRVKLAKELSRRATGQTLYILDEPTTGLHFEDVRKLLEVLHQLVEQGNTVVVIEHNLDVIKTADWVLDLGPEGGVKGGEIVAEGTPEVVAKAKGSFTGRYLAPLLTGR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP022672
EMBL· GenBank· DDBJ
BCA60447.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp