A0A6S6AA17 · G430_FUSSX
- ProteinCytochrome P450 monooxygenase g430
- Geneg430
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids571 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of 1233A, a natural compound known as an inhibitor of HMG-CoA synthase in the mevalonate pathway and with antibacterial and antifungal activities (PubMed:32139880).
The highly reducing polyketide synthase g433 is responsible for the 1233A backbone biosynthesis and the cytochrome P450 monooxygenase g430 catalyzes oxidation of the backbone (Probable)
The highly reducing polyketide synthase g433 is responsible for the 1233A backbone biosynthesis and the cytochrome P450 monooxygenase g430 catalyzes oxidation of the backbone (Probable)
Cofactor
Pathway
Mycotoxin biosynthesis.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome P450 monooxygenase g430
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium
Accessions
- Primary accessionA0A6S6AA17
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 8-28 | Helical | ||||
Sequence: GALIWVVTSYILYAIISNFII |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Impairs the ability to produce 1233A and its hydrolysis product 1233B.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000454629 | 1-571 | Cytochrome P450 monooxygenase g430 | |||
Sequence: MQISSAFGALIWVVTSYILYAIISNFIISRRHAAKARELKCEEPPFEKNRWPLGIDNLLRALAADKAQQFPVDIIKRFEDLGAHTYRYQILGARNIRTADPKNIQTILANKFNDFDVGPSRRGNFLPMLGNGIFTADGDHWKHSRAIIRPQFTRDQVSDLNLEETHVQNLMKLIGPMIGSNGWIEQIDLLPYFFRLTIDSATEFLFGEPVNSQLRFLPGYQSSKLGSKEERFATAFDSGQMALATRSRFMDSWWLYDSLAFRNSCKIVHDFVDHFVQLALSRGLREKVSDTNSGGKEQYIFLEAIAAETQNPTELRSELLHVLLAGRDTTASHLGWVFHNLARDPVRYKKLRDIIIDEFGTYENPSEITFAKLKACKYLRYVNDESLRLYPVVPINARYANKDTTLPRGGGKDGNSPIFIPKGSSTDFSVHVMHRRKDIWGPDADEFKPERWEGRKVGWEYLPFNGGPRICIGQQFALIEASYVTVRLLQRFDRMESLDKDAVVGHNLTLINCIANGVKTRSSIEFDGQTSQNDDQLRTIVEKPLVQKRSRCPLPAEAKLPKSRKPIGTAS |
Expression
Induction
Expression is increased upon exposure to hygromycin B.
Structure
Sequence
- Sequence statusComplete
- Length571
- Mass (Da)64,978
- Last updated2020-12-02 v1
- ChecksumB1423E5558C12BBC