A0A6S6AA17 · G430_FUSSX

  • Protein
    Cytochrome P450 monooxygenase g430
  • Gene
    g430
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Organism
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of 1233A, a natural compound known as an inhibitor of HMG-CoA synthase in the mevalonate pathway and with antibacterial and antifungal activities (PubMed:32139880).
The highly reducing polyketide synthase g433 is responsible for the 1233A backbone biosynthesis and the cytochrome P450 monooxygenase g430 catalyzes oxidation of the backbone (Probable)

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Mycotoxin biosynthesis.

Features

Showing features for binding site.

157150100150200250300350400450500550
TypeIDPosition(s)Description
Binding site471Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome P450 monooxygenase g430
  • EC number
  • Alternative names
    • 1233A biosynthesis cluster protein g430

Gene names

    • Name
      g430

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RK97-94
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium

Accessions

  • Primary accession
    A0A6S6AA17

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane8-28Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Impairs the ability to produce 1233A and its hydrolysis product 1233B.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004546291-571Cytochrome P450 monooxygenase g430

Expression

Induction

Expression is increased upon exposure to hygromycin B.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region552-571Disordered

Sequence similarities

Belongs to the cytochrome P450 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    571
  • Mass (Da)
    64,978
  • Last updated
    2020-12-02 v1
  • Checksum
    B1423E5558C12BBC
MQISSAFGALIWVVTSYILYAIISNFIISRRHAAKARELKCEEPPFEKNRWPLGIDNLLRALAADKAQQFPVDIIKRFEDLGAHTYRYQILGARNIRTADPKNIQTILANKFNDFDVGPSRRGNFLPMLGNGIFTADGDHWKHSRAIIRPQFTRDQVSDLNLEETHVQNLMKLIGPMIGSNGWIEQIDLLPYFFRLTIDSATEFLFGEPVNSQLRFLPGYQSSKLGSKEERFATAFDSGQMALATRSRFMDSWWLYDSLAFRNSCKIVHDFVDHFVQLALSRGLREKVSDTNSGGKEQYIFLEAIAAETQNPTELRSELLHVLLAGRDTTASHLGWVFHNLARDPVRYKKLRDIIIDEFGTYENPSEITFAKLKACKYLRYVNDESLRLYPVVPINARYANKDTTLPRGGGKDGNSPIFIPKGSSTDFSVHVMHRRKDIWGPDADEFKPERWEGRKVGWEYLPFNGGPRICIGQQFALIEASYVTVRLLQRFDRMESLDKDAVVGHNLTLINCIANGVKTRSSIEFDGQTSQNDDQLRTIVEKPLVQKRSRCPLPAEAKLPKSRKPIGTAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LC516401
EMBL· GenBank· DDBJ
BBU37365.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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