A0A6Q8PHP0 · A0A6Q8PHP0_HUMAN
- ProteinCytosolic purine 5'-nucleotidase
- GeneNT5C2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids569 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- AMP + inosine = adenosine + IMP
- CMP + inosine = cytidine + IMP
- GMP + H2O = guanosine + phosphateThis reaction proceeds in the forward direction.
- GMP + inosine = guanosine + IMP
- H2O + XMP = phosphate + xanthosineThis reaction proceeds in the forward direction.
- dGMP + H2O = 2'-deoxyguanosine + phosphateThis reaction proceeds in the forward direction.
- dGMP + inosine = 2'-deoxyguanosine + IMP
- dIMP + H2O = 2'-deoxyinosine + phosphateThis reaction proceeds in the forward direction.
- dIMP + inosine = 2'-deoxyinosine + IMP
- inosine + UMP = IMP + uridine
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 5'-nucleotidase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | transferase activity | |
Biological Process | GMP metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytosolic purine 5'-nucleotidase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A6Q8PHP0
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 389 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 4 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 416 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 426 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 510 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 519 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 537 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 546-569 | Disordered | ||||
Sequence: PLAPQEITHCHDEDDDEEEEEEEE |
Sequence similarities
Belongs to the 5'(3')-deoxyribonucleotidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length569
- Mass (Da)65,867
- Last updated2020-12-02 v1
- Checksum257E7C4CE9E96420
Computationally mapped potential isoform sequences
There are 10 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P49902 | 5NTC_HUMAN | NT5C2 | 561 | ||
A0A6Q8PFH2 | A0A6Q8PFH2_HUMAN | NT5C2 | 185 | ||
A0A6Q8PG36 | A0A6Q8PG36_HUMAN | NT5C2 | 222 | ||
A0A6Q8PEZ2 | A0A6Q8PEZ2_HUMAN | NT5C2 | 61 | ||
A0A6Q8PF50 | A0A6Q8PF50_HUMAN | NT5C2 | 40 | ||
A0A6Q8PHB5 | A0A6Q8PHB5_HUMAN | NT5C2 | 436 | ||
H0YHR8 | H0YHR8_HUMAN | NT5C2 | 157 | ||
Q5JUV6 | Q5JUV6_HUMAN | NT5C2 | 146 | ||
S4R3E7 | S4R3E7_HUMAN | NT5C2 | 44 | ||
S4R3A6 | S4R3A6_HUMAN | NT5C2 | 62 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL139817 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL360001 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL591408 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |