A0A6Q8PHG6 · A0A6Q8PHG6_HUMAN
- ProteinEndoribonuclease Dicer
- GeneDICER1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids563 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | catalytic activity, acting on a nucleic acid | |
Molecular Function | DNA binding | |
Molecular Function | hydrolase activity | |
Biological Process | regulation of gene expression |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A6Q8PHG6
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 3,574 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 51-227 | Helicase ATP-binding | ||||
Sequence: LLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVNASWTKERWNQEFTKHQVLIMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLE | ||||||
Region | 409-433 | Disordered | ||||
Sequence: YVSWSDSEDDDEDEEIEEKEKPETN | ||||||
Compositional bias | 412-427 | Acidic residues | ||||
Sequence: WSDSEDDDEDEEIEEK | ||||||
Domain | 433-563 | Helicase C-terminal | ||||
Sequence: NFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIML |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length563
- Mass (Da)64,633
- Last updated2020-12-02 v1
- ChecksumF66FE887FD289340
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9UPY3 | DICER_HUMAN | DICER1 | 1922 | ||
A0A6Q8PFV4 | A0A6Q8PFV4_HUMAN | DICER1 | 1090 | ||
A0A6Q8PH99 | A0A6Q8PH99_HUMAN | DICER1 | 522 | ||
H0YJZ6 | H0YJZ6_HUMAN | DICER1 | 1715 | ||
F6SZ09 | F6SZ09_HUMAN | DICER1 | 96 | ||
A0A7I2YBM0 | A0A7I2YBM0_HUMAN | DICER1 | 1802 | ||
Q5D0K5 | Q5D0K5_HUMAN | DICER1 | 70 | ||
A0A8Q3WLH6 | A0A8Q3WLH6_HUMAN | DICER1 | 133 | ||
A0A8Q3WLH8 | A0A8Q3WLH8_HUMAN | DICER1 | 1868 | ||
A0A8Q3WLJ5 | A0A8Q3WLJ5_HUMAN | DICER1 | 1789 | ||
A0A8Q3SJI0 | A0A8Q3SJI0_HUMAN | DICER1 | 1790 |
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 412-427 | Acidic residues | ||||
Sequence: WSDSEDDDEDEEIEEK | ||||||
Non-terminal residue | 563 | |||||
Sequence: L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL356017 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL390254 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |