A0A6Q8PGW4 · A0A6Q8PGW4_HUMAN

  • Protein
    glycine--tRNA ligase
  • Gene
    GARS1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionglycine-tRNA ligase activity
Molecular Functionidentical protein binding
Biological Processglycyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    glycine--tRNA ligase
  • EC number
  • Alternative names
    • Diadenosine tetraphosphate synthetase

Gene names

    • Name
      GARS1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A6Q8PGW4

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

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The viewer provides 595 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)206PRIDEPhosphoserine
Modified residue (large scale data)212PRIDEPhosphoserine
Modified residue (large scale data)330PRIDEPhosphotyrosine
Modified residue (large scale data)344PRIDEPhosphotyrosine
Modified residue (large scale data)528PRIDEPhosphoserine
Modified residue (large scale data)530PRIDEPhosphoserine

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain139-485Aminoacyl-transfer RNA synthetases class-II family profile

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    616
  • Mass (Da)
    69,932
  • Last updated
    2020-12-02 v1
  • Checksum
    704D7941E357EC07
MEDTLKRRFFYDQAFAIYGGVSGLYDFGPVGCALKNNIIQTWRQHFIQEEQILEIDCTMLTPEPVLKTSGHVDKFADFMVKDVKNGECFRADHLLKAHLQKLMSDKKCSVEKKSEMESVLAQLDNYGQQELADLFVNYNVKSPITGNDLSPPVSFNLMFKTFIGPGGNMPGYLRPETAQGIFLNFKRLLEFNQGKLPFAAAQIGNSFRNEISPRSGLIRVREFTMAEIEHFVDPSEKDHPKFQNVADLHLYLYSAKAQVSGQSARKMRLGDAVEQGVINNTVLGYFIGRIYLYLTKVGISPDKLRFRQHMENEMAHYACDCWDAESKTSYGWIEIVGCADRSCYDLSCHARATKVPLVAEKPLKEPKTVNVVQFEPSKGAIGKAYKKDAKLVMEYLAICDECYITEMEMLLNEKGEFTIETEGKTFQLTKDMINVKRFQKTLYVEEVVPNVIEPSFGLGRIMYTVFEHTFHVREGDEQRTFFSFPAVVAPFKCSVLPLSQNQEFMPFVKELSEALTRHGVSHKVDDSSGSIGRRYARTDEIGVAFGVTIDFDTVNKTPHTATLRDRDSMRQIRAEISELPSIVQDLANGNITWADVEARYPLFEGQETGKKETIEE

Computationally mapped potential isoform sequences

There are 17 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P41250GARS_HUMANGARS1739
A0A6Q8PFV5A0A6Q8PFV5_HUMANGARS1190
A0A6Q8PFZ6A0A6Q8PFZ6_HUMANGARS1546
A0A6Q8PFN0A0A6Q8PFN0_HUMANGARS179
A0A6Q8PFU7A0A6Q8PFU7_HUMANGARS1165
A0A6Q8PGI6A0A6Q8PGI6_HUMANGARS1672
A0A6Q8PGN7A0A6Q8PGN7_HUMANGARS1260
A0A6Q8PGA8A0A6Q8PGA8_HUMANGARS1683
A0A6Q8PGT3A0A6Q8PGT3_HUMANGARS1135
A0A6Q8PGZ8A0A6Q8PGZ8_HUMANGARS1745
A0A6Q8PGZ9A0A6Q8PGZ9_HUMANGARS1245
A0A6Q8PH49A0A6Q8PH49_HUMANGARS1350
A0A6Q8PF45A0A6Q8PF45_HUMANGARS1350
A0A6Q8PHH9A0A6Q8PHH9_HUMANGARS1705
A0A6Q8PHI7A0A6Q8PHI7_HUMANGARS1606
F8WCK4F8WCK4_HUMANGARS1255
H7C443H7C443_HUMANGARS1570

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC004976
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC005154
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC006969
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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