A0A6Q8PFS9 · A0A6Q8PFS9_HUMAN
- ProteinSodium leak channel, non-selective
- GeneNALCN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1767 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | monoatomic cation channel activity |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea (apes) > Hominidae (great apes) > Homininae > Homo
Accessions
- Primary accessionA0A6Q8PFS9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 41-61 | Helical | ||||
Sequence: LLRICAIISVISVCMNTPMTF | ||||||
Transmembrane | 67-88 | Helical | ||||
Sequence: LQYVTFTLDTLLMFLYTAEMIA | ||||||
Transmembrane | 108-127 | Helical | ||||
Sequence: CVFDGFMVFCLWVSLVLQVF | ||||||
Transmembrane | 139-158 | Helical | ||||
Sequence: WGMLRIPRPLIMIRAFRIYF | ||||||
Transmembrane | 178-195 | Helical | ||||
Sequence: IWSVSIFLLFFLLLYGIL | ||||||
Transmembrane | 299-322 | Helical | ||||
Sequence: YFYFITLIFFLAWLVKNVFIAVII | ||||||
Transmembrane | 385-406 | Helical | ||||
Sequence: VFHMFILSMVTVDVIVAASNYY | ||||||
Transmembrane | 418-446 | Helical | ||||
Sequence: FYLAEVAFTVLFDLEALLKIWCLGFTGYI | ||||||
Transmembrane | 506-528 | Helical | ||||
Sequence: LGSLVVFTASLLIVMSAISLQMF | ||||||
Transmembrane | 575-599 | Helical | ||||
Sequence: VAIYFILYHLFATLILLSLFVAVIL | ||||||
Transmembrane | 910-934 | Helical | ||||
Sequence: LLGLVTYLDWVMIIVTICSCISMMF | ||||||
Transmembrane | 985-1003 | Helical | ||||
Sequence: VMDIFIYLVSLIFLCWMPQ | ||||||
Transmembrane | 1046-1069 | Helical | ||||
Sequence: IFLVSILLLTLMLVFASFGVQLFA | ||||||
Transmembrane | 1163-1186 | Helical | ||||
Sequence: IYIHVFVFLGCMIGLTLFVGVVIA | ||||||
Transmembrane | 1240-1260 | Helical | ||||
Sequence: FFKRTIALLVLAQSVLLSVKW | ||||||
Transmembrane | 1266-1285 | Helical | ||||
Sequence: VTVPLATMSVVFTFIFVLEV | ||||||
Transmembrane | 1305-1323 | Helical | ||||
Sequence: YDLLVTSLGVVWVVLHFAL | ||||||
Transmembrane | 1365-1387 | Helical | ||||
Sequence: FFIIVGMFLLLLCYAFAGVVLFG | ||||||
Transmembrane | 1452-1476 | Helical | ||||
Sequence: ALMYFCSFYVIIAYIMLNLLVAIIV |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,379 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-331 | Ion transport | ||||
Sequence: PWVHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETFAEIRVQ | ||||||
Domain | 384-604 | Ion transport | ||||
Sequence: SVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILDNLEL | ||||||
Region | 791-810 | Disordered | ||||
Sequence: QERRSLRHGSNSQRISRGKS | ||||||
Coiled coil | 827-856 | |||||
Sequence: AQREDSEIKMIQEKKEQAEMKRKVQEEELR | ||||||
Domain | 916-1192 | Ion transport | ||||
Sequence: YLDWVMIIVTICSCISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFVFLGCMIGLTLFVGVVIANFNENK | ||||||
Domain | 1238-1486 | Ion transport | ||||
Sequence: HPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTE | ||||||
Compositional bias | 1640-1680 | Polar residues | ||||
Sequence: PPSIETTQPSEDTNANSQDNSMQPETSSQQQLLSPTLSDRG | ||||||
Region | 1640-1707 | Disordered | ||||
Sequence: PPSIETTQPSEDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKP |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,767
- Mass (Da)203,456
- Last updated2020-12-02 v1
- Checksum42DAD670F2408C27
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8IZF0 | NALCN_HUMAN | NALCN | 1738 | ||
A0A6Q8PFJ2 | A0A6Q8PFJ2_HUMAN | NALCN | 801 | ||
A0A6Q8PG91 | A0A6Q8PG91_HUMAN | NALCN | 170 | ||
A0A6Q8PGX7 | A0A6Q8PGX7_HUMAN | NALCN | 224 | ||
A0A6Q8PF19 | A0A6Q8PF19_HUMAN | NALCN | 1709 | ||
A0A6Q8PHC5 | A0A6Q8PHC5_HUMAN | NALCN | 256 | ||
A0A6Q8PHH0 | A0A6Q8PHH0_HUMAN | NALCN | 1645 | ||
A0A3B3ISV8 | A0A3B3ISV8_HUMAN | NALCN | 1522 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1640-1680 | Polar residues | ||||
Sequence: PPSIETTQPSEDTNANSQDNSMQPETSSQQQLLSPTLSDRG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL138707 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL354891 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL356778 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF455824 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF511189 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |