A0A6P5QKR3 · A0A6P5QKR3_MUSCR
- ProteinE3 ubiquitin-protein ligase Mdm2
- GeneMdm2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids494 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Molecular Function | identical protein binding | |
Molecular Function | metal ion binding | |
Molecular Function | p53 binding | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of biological quality | |
Biological Process | regulation of cell cycle | |
Biological Process | regulation of gene expression |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase Mdm2
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A6P5QKR3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-23 | Disordered | ||||
Sequence: MCNTNMSVSTEGAASTSQIPASE | ||||||
Domain | 26-109 | DM2 | ||||
Sequence: TLVRPKPLLLKLLKSVGAQNDTYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVA | ||||||
Region | 115-183 | Disordered | ||||
Sequence: SGTSLRESRCQPEGGSDLKDPVQAPPEEKPSSSDLVSRPSTSSRRRSISETEENTGELPGERHRKRRRS | ||||||
Compositional bias | 159-183 | Basic and acidic residues | ||||
Sequence: RRSISETEENTGELPGERHRKRRRS | ||||||
Compositional bias | 203-221 | Polar residues | ||||
Sequence: GGGSSSSSSSSSSSESTET | ||||||
Region | 203-242 | Disordered | ||||
Sequence: GGGSSSSSSSSSSSESTETPSHQDLDDGVSEHSGDCLDQD | ||||||
Compositional bias | 222-240 | Basic and acidic residues | ||||
Sequence: PSHQDLDDGVSEHSGDCLD | ||||||
Compositional bias | 255-273 | Acidic residues | ||||
Sequence: ESLDSEDYSLSDEGHELSD | ||||||
Region | 255-276 | Disordered | ||||
Sequence: ESLDSEDYSLSDEGHELSDEDD | ||||||
Domain | 302-331 | RanBP2-type | ||||
Sequence: LADYWKCTSCSEMNPPLPSHCKRCWTLREN | ||||||
Compositional bias | 336-391 | Basic and acidic residues | ||||
Sequence: DKGKEKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPL | ||||||
Region | 336-431 | Disordered | ||||
Sequence: DKGKEKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPLSQESDDYSQPSTSSSIVYSSQESVKELREETQDKEESVES | ||||||
Compositional bias | 392-413 | Polar residues | ||||
Sequence: SQESDDYSQPSTSSSIVYSSQE | ||||||
Compositional bias | 414-428 | Basic and acidic residues | ||||
Sequence: SVKELREETQDKEES | ||||||
Domain | 441-482 | RING-type | ||||
Sequence: CVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCR |
Sequence similarities
Belongs to the MDM2/MDM4 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length494
- Mass (Da)54,902
- Last updated2020-12-02 v1
- Checksum69DC778AAFAE596C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 159-183 | Basic and acidic residues | ||||
Sequence: RRSISETEENTGELPGERHRKRRRS | ||||||
Compositional bias | 203-221 | Polar residues | ||||
Sequence: GGGSSSSSSSSSSSESTET | ||||||
Compositional bias | 222-240 | Basic and acidic residues | ||||
Sequence: PSHQDLDDGVSEHSGDCLD | ||||||
Compositional bias | 255-273 | Acidic residues | ||||
Sequence: ESLDSEDYSLSDEGHELSD | ||||||
Compositional bias | 336-391 | Basic and acidic residues | ||||
Sequence: DKGKEKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPL | ||||||
Compositional bias | 392-413 | Polar residues | ||||
Sequence: SQESDDYSQPSTSSSIVYSSQE | ||||||
Compositional bias | 414-428 | Basic and acidic residues | ||||
Sequence: SVKELREETQDKEES |