A0A6P3TA66 · A0A6P3TA66_SHEEP

  • Protein
    Cryptochrome-1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Cofactor

Protein has several cofactor binding sites:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate (UniProtKB | Rhea| CHEBI:15636 )

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, site.

158750100150200250300350400450500550
TypeIDPosition(s)Description
Binding site289-296FAD (UniProtKB | ChEBI)
Site320Electron transfer via tryptophanyl radical
Site374Electron transfer via tryptophanyl radical
Binding site387-389FAD (UniProtKB | ChEBI)
Site397Electron transfer via tryptophanyl radical

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular FunctionE-box binding
Molecular FunctionFAD binding
Molecular Functionhistone deacetylase binding
Molecular Functionnuclear receptor binding
Molecular Functionphosphatase binding
Molecular Functionphotoreceptor activity
Molecular Functionprotein kinase binding
Biological Processcircadian regulation of gene expression
Biological Processentrainment of circadian clock by photoperiod
Biological Processgluconeogenesis
Biological Processglucose homeostasis
Biological Processlipid storage
Biological Processnegative regulation of circadian rhythm
Biological Processnegative regulation of G protein-coupled receptor signaling pathway
Biological Processnegative regulation of glucocorticoid receptor signaling pathway
Biological Processnegative regulation of glucocorticoid secretion
Biological Processnegative regulation of gluconeogenesis
Biological Processnegative regulation of protein ubiquitination
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of gluconeogenesis
Biological Processpositive regulation of protein ubiquitination
Biological Processregulation of DNA damage checkpoint
Biological Processresponse to activity
Biological Processresponse to glucagon
Biological Processresponse to insulin
Biological Processsignal transduction in response to DNA damage

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cryptochrome-1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis

Accessions

  • Primary accession
    A0A6P3TA66
  • Secondary accessions
    • B3F206

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-132Photolyase/cryptochrome alpha/beta

Sequence similarities

Belongs to the DNA photolyase class-1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    587
  • Mass (Da)
    66,454
  • Last updated
    2020-12-02 v1
  • Checksum
    4EEA4025338CE66D
MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDSEPFGKERDAAIKKLATEAGVEVIIRISHTLYDLDKIIELNGGQPPLTYKRFQTLISKMEPLEIPVETITSEVMEKCTTPLSDDHDEKYGVPSLEELGFDTDGLPSAVWPGGETEALTRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGRTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSINAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNAPEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLASVPSNPNGNGGLMGYSPGENIPGCSSSASCTQGSGILHYAHGDSQQTHLLKQGRSSTAAGLGSGKRPSQEEDTQSVGPKVQRQSTN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EF494243
EMBL· GenBank· DDBJ
ABS44879.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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