A0A6P1IGI4 · A0A6P1IGI4_9BURK

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site84substrate
Binding site225-227substrate
Binding site234Mn2+ (UniProtKB | ChEBI)
Binding site254Mn2+ (UniProtKB | ChEBI)
Binding site276substrate
Binding site277-282GTP (UniProtKB | ChEBI)
Active site278
Binding site303Mn2+ (UniProtKB | ChEBI)
Binding site396-398substrate
Binding site398GTP (UniProtKB | ChEBI)
Binding site429GTP (UniProtKB | ChEBI)
Binding site526-529GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      F9Z45_00840

Organism names

  • Taxonomic identifier
  • Strain
    • PBL-H3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Hydrogenophaga

Accessions

  • Primary accession
    A0A6P1IGI4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    618
  • Mass (Da)
    67,800
  • Last updated
    2020-10-07 v1
  • MD5 Checksum
    802ADDBF9AA4CDAF3CF2EB30B83935E9
MNSPVMQGLTLNTPSYVKNARLIAWVADMAALCKPDTVVWCDGSDEEYARLCEQLVSAGTMKRLNPIKRPNSFLACSDPSDVARVEDRTFICSQKQEDAGPTNNWKAPAEMRATLQPLFDGCMRGRTMYVVPFSMGPLGSPIAHIGIELSDSAYVAVNMKLMTRMGKAVFDVLGTDGEFVPCVHTVGAPLAAGETDKTGWPCNPTTKYIVHYPETREIWSYGSGYGGNALLGKKCFALRIASTMGKQQGWLAEHMLILGVTNPQGKKYHVAAAFPSACGKTNFAMLIPPKGFEGWSVTTIGDDIAWIKPHADGRLYAINPEAGYFGVAPGTNTLTNPNCMASLDRDVVFTNVALTDDGDVWWEGMGEAPAHAIDWQGKDWTPQIAKETGAKAAHPNARFTVAATNNPALDPAWDDPSGVPIDAFIFGGRRSTTVPLVTEARDWTEGVYMAATMGSETTAAAFGAQGVVRRDPFAMLPFTGYNMSDYFQHWLDMGNKLTSQGAKLPGIFCVNWFRKDEAGKFVWPGFGENMRVLKWMIDRLEGQGQGTEHAFGVSPRYEDIHWDGLNFSTEQYNTVTHIDSAAWTQELALHSELFTQLAHHLPRELEETKAKIEKRLAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP044975
EMBL· GenBank· DDBJ
QHE74689.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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