A0A6P1BFZ5 · A0A6P1BFZ5_9BRAD

  • Protein
    Shikimate dehydrogenase (NADP(+))
  • Gene
    aroE
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site67shikimate (UniProtKB | ChEBI)
Active site71Proton acceptor
Binding site92shikimate (UniProtKB | ChEBI)
Binding site107shikimate (UniProtKB | ChEBI)
Binding site131-135NADP+ (UniProtKB | ChEBI)
Binding site219NADP+ (UniProtKB | ChEBI)
Binding site221shikimate (UniProtKB | ChEBI)
Binding site242NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      FNJ47_15350

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • UFLA 03-164
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Bradyrhizobium

Accessions

  • Primary accession
    A0A6P1BFZ5

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-94Shikimate dehydrogenase substrate binding N-terminal
Domain127-192THIF-type NAD/FAD binding fold

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    29,292
  • Last updated
    2020-10-07 v1
  • Checksum
    1A9BD7206EFBE031
MRDRFLTGLIGYPIAHSAAPAMHEQAAAALGVHCHYQLIEVKGAGRDDLRAMLDGVRRLGFAGVNVTFPYKEAVIDLIDDLAPDARAIGAVNTIVVDGARLVGHNTDATGFARAIEPLLAASPRGPIALIGAGGVGKAIAFALAGFGVGELRIFDADAAKAAQLAGQLQDRHAVHAASVEIAVEAAAGLVNATPVGMLPSRETPVPDALLHSSMWVADAAYTPLWTPLLTTAKARGANVLTGRDLAINASADAFKLFTGLTPPHDAMANAFDAVMAARYAPPAT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VKHP01000052
EMBL· GenBank· DDBJ
NEU97173.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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