A0A6N8HIX2 · A0A6N8HIX2_9BACI
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids160 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10 | substrate | |||
Binding site | 10-11 | ATP (UniProtKB | ChEBI) | |||
Binding site | 18 | ATP (UniProtKB | ChEBI) | |||
Site | 18 | Transition state stabilizer | |||
Binding site | 42 | substrate | |||
Binding site | 74 | substrate | |||
Binding site | 88 | substrate | |||
Binding site | 89-91 | ATP (UniProtKB | ChEBI) | |||
Binding site | 99 | ATP (UniProtKB | ChEBI) | |||
Binding site | 124-130 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Lentibacillus
Accessions
- Primary accessionA0A6N8HIX2
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Sequence
- Sequence statusComplete
- Length160
- Mass (Da)18,078
- Last updated2020-10-07 v1
- Checksum76E7A2D7948A6208
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
WHOH01000001 EMBL· GenBank· DDBJ | MUV36240.1 EMBL· GenBank· DDBJ | Genomic DNA |