A0A6M8U741 · A0A6M8U741_9GAMM
- ProteinATP-dependent DNA helicase DinG
- GenedinG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids720 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
DNA-dependent ATPase and 5'-3' DNA helicase. Unwinds D-loops, R-loops, forked DNA and G-quadruplex DNA.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | metal ion binding | |
Biological Process | nucleobase-containing compound metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase DinG
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae
Accessions
- Primary accessionA0A6M8U741
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-293 | Helicase ATP-binding | ||||
Sequence: ALQQQVPDFIPRSPQRQMIAEVAKTLAGDDGRHLAIEAPTGVGKTLAYLIPGIAVSRAEEKPLIVSTANVALQDQIFSKDLPLLKKIIPELKFTAAFGRGRYVCPRNLSALATDADKQGDLPLFLDDDLTASKEEQALCVRLEKNLNRYQWDGLRDHCDEAIDDGLWQRLSTDKANCLGRNCHWFRECPFFVARREIEQADVVVANHALVMAALENESVLPPAKQLLLVLDEGHHLPDVARDALEMSGDITPGWNALQLDLFVRLVEQCMAQFRPKS |
Sequence similarities
Family and domain databases
Sequence
- Sequence statusComplete
- Length720
- Mass (Da)81,186
- Last updated2020-10-07 v1
- Checksum3D0C0C7875E7757A
Keywords
- Technical term