A0A6M8NT94 · A0A6M8NT94_ONCMY

Function

Catalytic activity

  • 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoA
    This reaction proceeds in the forward direction.
  • 1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA
    This reaction proceeds in the forward direction.
  • 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoA
    This reaction proceeds in the forward direction.
  • 2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoA
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoA
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoA
    This reaction proceeds in the forward direction.
  • 13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA
    This reaction proceeds in the forward direction.
  • 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoA
    This reaction proceeds in the forward direction.
  • an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.20 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.76 (UniProtKB | ENZYME | Rhea)
  • all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
    This reaction proceeds in the forward direction.
  • hexadecan-1-ol + hexadecanoyl-CoA = hexadecanyl hexadecanoate + CoA
    This reaction proceeds in the forward direction.
  • hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoA
    This reaction proceeds in the forward direction.
  • hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoA
    This reaction proceeds in the forward direction.

Pathway

Lipid metabolism; glycerolipid metabolism.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site442

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functiondiacylglycerol O-acyltransferase activity
Molecular Functionretinol O-fatty-acyltransferase activity
Biological Processtriglyceride biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    O-acyltransferase

Gene names

    • Name
      dgat1

Organism names

Accessions

  • Primary accession
    A0A6M8NT94

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane106-123Helical
Transmembrane149-168Helical
Transmembrane184-204Helical
Transmembrane210-227Helical
Transmembrane309-328Helical
Transmembrane350-369Helical
Transmembrane428-447Helical
Transmembrane453-475Helical
Transmembrane482-500Helical

Keywords

Interaction

Subunit

Homodimer or homotetramer; both forms have similar enzymatic activities.

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-76Disordered
Compositional bias22-54Polar residues
Compositional bias55-76Basic and acidic residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    512
  • Mass (Da)
    59,317
  • Last updated
    2020-10-07 v1
  • MD5 Checksum
    EB55E4AC68FC6340AB6995C097E97C57
MYQISEMVDRNDRVPMMTGRTRRSTIGPTPAGGNSKQANGSKQSSAGEKTPSHPSHSNGKVKKEKQVHEPVRTPQERSKICERLSCHVLQESLLSSASGYSNYRGILNWCVVMLVLSNARLFLENLLKYGILVDPIQVVSLFLKDPYSWPAPCLVIVSNVFIMAALYTERRLSVGTISETTGTFLYLVNLTTLLCFPSATVLTLTSMTPAGGVFALGVYTILFMKLYSYKDVNMWCREIRHTKARTLTRSHSCPSVAQSNGSAVHSHVSYPGNLTHRDIYYFVFAPTLCYELNFPRSPRIRKSFLLRRLFEMLFFIQLLIGLVQQWIVPTIQNSMKPFQDMDFSRMMERMLKLAVPNHLIWLIFFYWFFHSSMNFVAELMQFGDREFYRDWWNSETVTYFWSNWNIPVHKWCLRHFYKPIMRRGVNKWVAQTAVFLVSAFFHEYLVSVPLKMFRLWAFMGMMSQIPLAWFVGRFLRGNHGNAAVWISLIIGQPVAVLMYVHDYYVIHYMSQS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias22-54Polar residues
Compositional bias55-76Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN480465
EMBL· GenBank· DDBJ
QKG02513.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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