A0A6M6AM59 · A0A6M6AM59_KONPU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    A0A6M6AM59

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-40Helical
Transmembrane61-85Helical
Transmembrane105-128Helical
Transmembrane140-167Helical
Transmembrane200-218Helical
Transmembrane225-248Helical
Transmembrane260-282Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-291Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    291
  • Mass (Da)
    31,577
  • Last updated
    2020-10-07 v1
  • Checksum
    DA5B60D784649E3F
PGALLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLSGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKW

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue291

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT381749
EMBL· GenBank· DDBJ
QJX19985.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381750
EMBL· GenBank· DDBJ
QJX19986.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381751
EMBL· GenBank· DDBJ
QJX19987.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381752
EMBL· GenBank· DDBJ
QJX19988.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381753
EMBL· GenBank· DDBJ
QJX19989.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381754
EMBL· GenBank· DDBJ
QJX19990.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381755
EMBL· GenBank· DDBJ
QJX19991.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381756
EMBL· GenBank· DDBJ
QJX19992.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381757
EMBL· GenBank· DDBJ
QJX19993.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381758
EMBL· GenBank· DDBJ
QJX19994.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381759
EMBL· GenBank· DDBJ
QJX19995.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381760
EMBL· GenBank· DDBJ
QJX19996.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381761
EMBL· GenBank· DDBJ
QJX19997.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381762
EMBL· GenBank· DDBJ
QJX19998.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381763
EMBL· GenBank· DDBJ
QJX19999.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381764
EMBL· GenBank· DDBJ
QJX20000.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381765
EMBL· GenBank· DDBJ
QJX20001.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381766
EMBL· GenBank· DDBJ
QJX20002.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381767
EMBL· GenBank· DDBJ
QJX20003.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381768
EMBL· GenBank· DDBJ
QJX20004.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381769
EMBL· GenBank· DDBJ
QJX20005.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381770
EMBL· GenBank· DDBJ
QJX20006.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381771
EMBL· GenBank· DDBJ
QJX20007.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381772
EMBL· GenBank· DDBJ
QJX20008.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381773
EMBL· GenBank· DDBJ
QJX20009.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381774
EMBL· GenBank· DDBJ
QJX20010.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381775
EMBL· GenBank· DDBJ
QJX20011.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381776
EMBL· GenBank· DDBJ
QJX20012.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381777
EMBL· GenBank· DDBJ
QJX20013.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381778
EMBL· GenBank· DDBJ
QJX20014.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381779
EMBL· GenBank· DDBJ
QJX20015.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381780
EMBL· GenBank· DDBJ
QJX20016.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381781
EMBL· GenBank· DDBJ
QJX20017.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381782
EMBL· GenBank· DDBJ
QJX20018.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381783
EMBL· GenBank· DDBJ
QJX20019.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381784
EMBL· GenBank· DDBJ
QJX20020.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381785
EMBL· GenBank· DDBJ
QJX20021.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381786
EMBL· GenBank· DDBJ
QJX20022.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381787
EMBL· GenBank· DDBJ
QJX20023.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381788
EMBL· GenBank· DDBJ
QJX20024.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381789
EMBL· GenBank· DDBJ
QJX20025.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381790
EMBL· GenBank· DDBJ
QJX20026.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381791
EMBL· GenBank· DDBJ
QJX20027.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381792
EMBL· GenBank· DDBJ
QJX20028.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381793
EMBL· GenBank· DDBJ
QJX20029.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381794
EMBL· GenBank· DDBJ
QJX20030.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381795
EMBL· GenBank· DDBJ
QJX20031.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381796
EMBL· GenBank· DDBJ
QJX20032.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381797
EMBL· GenBank· DDBJ
QJX20033.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381798
EMBL· GenBank· DDBJ
QJX20034.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381799
EMBL· GenBank· DDBJ
QJX20035.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381800
EMBL· GenBank· DDBJ
QJX20036.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381801
EMBL· GenBank· DDBJ
QJX20037.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381802
EMBL· GenBank· DDBJ
QJX20038.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381803
EMBL· GenBank· DDBJ
QJX20039.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381804
EMBL· GenBank· DDBJ
QJX20040.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381805
EMBL· GenBank· DDBJ
QJX20041.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381806
EMBL· GenBank· DDBJ
QJX20042.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381807
EMBL· GenBank· DDBJ
QJX20043.1
EMBL· GenBank· DDBJ
Genomic DNA
MT381808
EMBL· GenBank· DDBJ
QJX20044.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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