A0A6M6AM59 · A0A6M6AM59_KONPU
- ProteinCytochrome c oxidase subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids291 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Clupei > Clupeiformes > Clupeoidei > Clupeidae > Konosirus
Accessions
- Primary accessionA0A6M6AM59
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-40 | Helical | ||||
Sequence: FVMIFFMVMPILIGGFGNWLV | ||||||
Transmembrane | 61-85 | Helical | ||||
Sequence: LLPPSFLLLLASSGVEAGAGTGWTV | ||||||
Transmembrane | 105-128 | Helical | ||||
Sequence: FSLHLAGISSILGAINFITTIINM | ||||||
Transmembrane | 140-167 | Helical | ||||
Sequence: LFVWAVLVTAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 200-218 | Helical | ||||
Sequence: VYILILPGFGMISHIVAYY | ||||||
Transmembrane | 225-248 | Helical | ||||
Sequence: FGYMGMVWAMMAIGLLGFIVWAHH | ||||||
Transmembrane | 260-282 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-291 | Cytochrome oxidase subunit I profile | ||||
Sequence: PGALLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLSGNLAHAGASVDLTIFSLHLAGISSILGAINFITTIINMKPPAISQYQTPLFVWAVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKW |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length291
- Mass (Da)31,577
- Last updated2020-10-07 v1
- ChecksumDA5B60D784649E3F
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: P | ||||||
Non-terminal residue | 291 | |||||
Sequence: W |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MT381749 EMBL· GenBank· DDBJ | QJX19985.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381750 EMBL· GenBank· DDBJ | QJX19986.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381751 EMBL· GenBank· DDBJ | QJX19987.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381752 EMBL· GenBank· DDBJ | QJX19988.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381753 EMBL· GenBank· DDBJ | QJX19989.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381754 EMBL· GenBank· DDBJ | QJX19990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381755 EMBL· GenBank· DDBJ | QJX19991.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381756 EMBL· GenBank· DDBJ | QJX19992.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381757 EMBL· GenBank· DDBJ | QJX19993.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381758 EMBL· GenBank· DDBJ | QJX19994.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381759 EMBL· GenBank· DDBJ | QJX19995.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381760 EMBL· GenBank· DDBJ | QJX19996.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381761 EMBL· GenBank· DDBJ | QJX19997.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381762 EMBL· GenBank· DDBJ | QJX19998.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381763 EMBL· GenBank· DDBJ | QJX19999.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381764 EMBL· GenBank· DDBJ | QJX20000.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381765 EMBL· GenBank· DDBJ | QJX20001.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381766 EMBL· GenBank· DDBJ | QJX20002.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381767 EMBL· GenBank· DDBJ | QJX20003.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381768 EMBL· GenBank· DDBJ | QJX20004.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381769 EMBL· GenBank· DDBJ | QJX20005.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381770 EMBL· GenBank· DDBJ | QJX20006.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381771 EMBL· GenBank· DDBJ | QJX20007.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381772 EMBL· GenBank· DDBJ | QJX20008.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381773 EMBL· GenBank· DDBJ | QJX20009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381774 EMBL· GenBank· DDBJ | QJX20010.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381775 EMBL· GenBank· DDBJ | QJX20011.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381776 EMBL· GenBank· DDBJ | QJX20012.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381777 EMBL· GenBank· DDBJ | QJX20013.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381778 EMBL· GenBank· DDBJ | QJX20014.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381779 EMBL· GenBank· DDBJ | QJX20015.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381780 EMBL· GenBank· DDBJ | QJX20016.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381781 EMBL· GenBank· DDBJ | QJX20017.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381782 EMBL· GenBank· DDBJ | QJX20018.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381783 EMBL· GenBank· DDBJ | QJX20019.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381784 EMBL· GenBank· DDBJ | QJX20020.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381785 EMBL· GenBank· DDBJ | QJX20021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381786 EMBL· GenBank· DDBJ | QJX20022.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381787 EMBL· GenBank· DDBJ | QJX20023.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381788 EMBL· GenBank· DDBJ | QJX20024.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381789 EMBL· GenBank· DDBJ | QJX20025.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381790 EMBL· GenBank· DDBJ | QJX20026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381791 EMBL· GenBank· DDBJ | QJX20027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381792 EMBL· GenBank· DDBJ | QJX20028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381793 EMBL· GenBank· DDBJ | QJX20029.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381794 EMBL· GenBank· DDBJ | QJX20030.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381795 EMBL· GenBank· DDBJ | QJX20031.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381796 EMBL· GenBank· DDBJ | QJX20032.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381797 EMBL· GenBank· DDBJ | QJX20033.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381798 EMBL· GenBank· DDBJ | QJX20034.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381799 EMBL· GenBank· DDBJ | QJX20035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381800 EMBL· GenBank· DDBJ | QJX20036.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381801 EMBL· GenBank· DDBJ | QJX20037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381802 EMBL· GenBank· DDBJ | QJX20038.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381803 EMBL· GenBank· DDBJ | QJX20039.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381804 EMBL· GenBank· DDBJ | QJX20040.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381805 EMBL· GenBank· DDBJ | QJX20041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381806 EMBL· GenBank· DDBJ | QJX20042.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381807 EMBL· GenBank· DDBJ | QJX20043.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT381808 EMBL· GenBank· DDBJ | QJX20044.1 EMBL· GenBank· DDBJ | Genomic DNA |