A0A6M5UPD0 · A0A6M5UPD0_9CALI

  • Protein
    Genome polyprotein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

function

Displays NTPase activity, but no helicase activity. Induces the formation of convoluted membranes derived from the host ER. These remodeled membranes probably form the viral factories that contain the replication complex. Together with NS2 and NS4, initiates the formation of the replication complex.
Probable key protein responsible for the formation of membrane alterations by the virus. Induces the formation of convoluted membranes derived from the host ER. These remodeled membranes probably form the viral factories that contain the replication complex. Together with NS2 and NTPase, initiates the formation of the replication complex.
Together with NTPase and NS4, initiates the formation of the replication complex. Induces the proliferation of the host smooth ER membranes forming long tubular structures. These remodeled membranes probably form the viral factories that contain the replication complex.
Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation. Interacts with host translation initiation complex to allow the translation of viral proteins.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological ProcessRNA-protein covalent cross-linking
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C86
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Sapovirus > Sapporo virus

Accessions

  • Primary accession
    A0A6M5UPD0

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain449-604SF3 helicase
Region930-953Disordered
Domain1051-1199Peptidase C24
Domain1438-1563RdRp catalytic

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    2,275
  • Mass (Da)
    250,587
  • Last updated
    2020-10-07 v1
  • Checksum
    94561E73D1143AAA
FYPIEFNHKVETTVLFSAHLRVSGREEIFETKQDMYAHVCQVITGVRREILRRTPVVGPSFSAEGLLDAFASKPPVDINPDTTFRELFGIDPHEQFPLSITDLAKLQGELVDAAHNPGHILRRHYSTDSLTKLINKITKYIPVQATLTEMQARRAHERERADLFKELPLVDPEITQQQKSYFYAMWRQVVKKGKEFFIPLVKCTSWRKKFSEPAEIVRQLLVHFCEGMRTQFNTNANYINLSLLAKLRPTVLTMIFQQHKNTYRGWLATITALVEVYSNLFQDMRETAVSAVSAITLLFESLKQFVEGVIDLVRGTFQAQGPTNCGWAAIAAGVILILLKISGCPSVMGYWQRLLKVCAGVTTIAAAARAFTWVRDIIVEAERKARLKKYMARTAALLELAASRDVTGTEELKRLLECFTQLIEEGTELIQEFGTSPMAGLARSYVSELETAANGIRSTILLDTPRKVPVAIILTGPPGIGKTHLAQHLAAGFGKTSNFSVTLDHHDSYTGNDVAIWDEFDVDAQGKFVETMIGVVNTAPYPLNCDRVENKGKVFTSNYIICTSNYPTSVLPENPRAGAFYRRVTTVDVSSPVIDDWKKKNPGKKPPLDLYKKDFSHLRLSVRPYLGYNPEGDTLEGVRVKPILTSVDGLSRLMETKFKEQGNELRNLWITCPRDLVTPAASGLKSYMAANRALAQVFAEPSSNEIAETCTSRIFVSANNPPPTFVGRHVKITAINPWDASLANSMLSMFETNTHIPAVTQREIMYRVWTPLIHMQTREPNTQMLPYINRVVPVTSSFDFVRGLRHHLGLCSIKGMWKAYQGWHSSATILEFLSKHMEDVTFPSNPECTVFRAADGDVIFYTFGSYACFVSPARVPFVGDPPKTVHSNITRNMTWIETLRLLVETITESLAHFGPLLLMVHNVTYLTTRSQRDEEAKGKTKHGRGARHARRGGVSLSDDEYDEWRDLVRDWRQDMTVGEFVELRERYALGMDSEDVQRYRAWLQLRAMRLGAGAYQHATIIGRGRVEDTIIRTQPMRAPRAPRSTGYDEEAPTPIVTFTSNGDHVGYGCHIGNGVVVTVTHVAAAADVVEGLEFTVRKTEGETTWVNTPLSHLPHYQLGDGAPVYYSTRLHPVTTIAEGTYETPNITVHGFHLRIINGYPTKRGDCGTPYFDSCRRLVGLHAATSTNGETKLAQKVSRVSKVENAFAWKGLPVLRGPDCGGMPTGTRYHRSPAWPEQLSNETHAPAPFGAGDSRYNFSQVEMLVTGLKPYSEPTPGIPPALLQRAATHTRTYLESIVGTHRSPNLTYNEACALLDRSTSCGPFIAGQKGDYWDEDRQCYTGVLAEHLGKAWDAANRGVAPQNAYKLALKDELRPIEKNQQGKRRLLWGCDAGATLVATAAFKGIATRLQAVAPMTPVGVGINMDSYQVEVLNESLKGGVVYCLDYSKWDSTQHPAVTAASLAILERLSEATPITTSAVELLSSPARGHLNDIIFVTKSGLPSGMPFTSVVNSLNHMTYFAAAVLKAYEQHGAPYTGNVFQVETVHTYGDDCIYSLCPATASIFETVLANLSAFGLRPTAADKTDKIAPTHTPIFLKRTLTCTPRGIRGLLDITSIRRQFFWIKANRTTDISSPPAYDREARSVQLENALAYASQHGHAIFEEIAEIAKKTAQAEGLVLTNVNYDQALATYEAWFIGGTGTGQDSPSEETTKLVFEMEGLGQSQSQRDQQVMDQVVTPQDTIGPTSALLLPTQVETPNASAQRVELAMATGAVTSNVPNCIRECFAAVTTIPWTTRQAANTFLGAIHLGPRINPYTAHLSAMFAGWGGGFQVRVTISGSGLFAGRAITAILPPGVNPAAVQNPGVFPHAFIDARTTDPILINLPDIRPIDFHRVDGDDATASVGLWVAQPLINPFQTGSVSTCWLSFETRPGPDFDFCLLKAPEQEMDNGISPANLLPRRLGRSRGNRLGGRVVGLVVVAAAEQVNHHFGANSTTLGWSTLPIEPIAGAVSWYDDNNEHTKIRGLLSAQGKGIIFPNIVNHWTDVSLSAKTSGQTTIPIAADNLNNSPGAAGPVVMFENNGDVNESTANHGILTAASHDFTSLSQTFDAAGLWVWMPWTRNKPDGRTNTNVYITPTWINGNPARPIHEKCTNMVGTNFQFGGTGTNNIMLWQEQHFTSFPGAAEVYCSQLESTAEMFQNNVVNIPANQMAVFNVETAGNTFQIGILPNGYSVTNAAIGTHQLLDYETSFRFVGLFPQSTSLQGPNGNAGRAVRFLE

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN794211
EMBL· GenBank· DDBJ
QJW39046.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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