A0A6M5UNF8 · A0A6M5UNF8_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3430 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1550 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1574 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1634 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2580 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2610 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2611 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2628 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2629 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2655 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2656 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2744 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2964 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2968 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2973 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2976 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3241 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3257 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3376 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus louisense
Accessions
- Primary accessionA0A6M5UNF8
Subcellular Location
UniProt Annotation
GO Annotation
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 741-762 | Helical | ||||
Sequence: LFGGMSWITQGLLGALLLWMGL | ||||||
Transmembrane | 769-789 | Helical | ||||
Sequence: ISLTLLAVGGILIFLATSVQA | ||||||
Transmembrane | 1139-1161 | Helical | ||||
Sequence: VTAGVAGGMEPFQLGLLVAFIAT | ||||||
Transmembrane | 1173-1195 | Helical | ||||
Sequence: LTLASLAVCLALLIVGNITYMDL | ||||||
Transmembrane | 1215-1236 | Helical | ||||
Sequence: VIHLALVAVFKVQPAFLAGLFL | ||||||
Transmembrane | 1266-1283 | Helical | ||||
Sequence: VLPILNAMSIAWMLIRAM | ||||||
Transmembrane | 1295-1324 | Helical | ||||
Sequence: ILCALIPGMRVAGLDVIRCLLLIIGIVTLL | ||||||
Transmembrane | 1336-1361 | Helical | ||||
Sequence: GGYLLAAALCQVGLCSPLIMMGGLIL | ||||||
Transmembrane | 1396-1414 | Helical | ||||
Sequence: SMVVPFAIAGLMYITYTVS | ||||||
Transmembrane | 1470-1493 | Helical | ||||
Sequence: FVLLGLSARFYWFIPFGVLGFWLL | ||||||
Transmembrane | 2171-2190 | Helical | ||||
Sequence: LLLIGMLCVMSMGTFIFLMN | ||||||
Transmembrane | 2197-2214 | Helical | ||||
Sequence: MGLGAFVITLATALLWAA | ||||||
Transmembrane | 2220-2237 | Helical | ||||
Sequence: QIAGVLLIVFLLMIVLIP | ||||||
Transmembrane | 2249-2266 | Helical | ||||
Sequence: QLAVFLICIMTLMGVVAA | ||||||
Transmembrane | 2308-2324 | Helical | ||||
Sequence: ATAWALYAAATMVMTPL | ||||||
Transmembrane | 2336-2359 | Helical | ||||
Sequence: FSLTAIASQAGVLLGLTNGMPFIS | ||||||
Transmembrane | 2379-2398 | Helical | ||||
Sequence: SLAAAVMLLAVHYAFMIPGW | ||||||
Transmembrane | 2445-2461 | Helical | ||||
Sequence: ILLIAAAVLAVLVRPGI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 291↔318 | |||||
Sequence: CLGTSNRDFVEGASGATWIDLVLEGGSC | ||||||
Disulfide bond | 348↔404 | |||||
Sequence: CYEATLDTLSTVARCPTTGEAHNTKRSDPTFVCKRDVVDRGWGNGCGLFGKGSIDTC | ||||||
Disulfide bond | 362↔393 | |||||
Sequence: CPTTGEAHNTKRSDPTFVCKRDVVDRGWGNGC | ||||||
Disulfide bond | 380↔409 | |||||
Sequence: CKRDVVDRGWGNGCGLFGKGSIDTCAKFTC | ||||||
Disulfide bond | 478↔576 | |||||
Sequence: CEARSGINTEDYYVFTVKEKSWLVNRDWFHDLNLPWTSPATTDWRNRETLVEFEEPHATKQTVVALGSQEGALHTALAGAIPATVSSSTLTLQSGHLKC | ||||||
Disulfide bond | 593↔624 | |||||
Sequence: CDSAFTFSKNPADTGHGTVIVELQYTGSNGPC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1369-1499 | Flavivirus NS2B | ||||
Sequence: SWPAGEVLTGVGLMCALAGGLLEFEETSMVVPFAIAGLMYITYTVSGKATEMWIEKAADITWEQNAEITGTSPRLDVDLDSHGNFKLLNDPGAPVHLFALRFVLLGLSARFYWFIPFGVLGFWLLGKHSKR | ||||||
Domain | 1500-1677 | Peptidase S7 | ||||
Sequence: GGALWDVPSPKVYPKCETKPGIYRIMTRGILGTFQAGVGVMHEGVFHTMWHATEGAVLRNGEGRLDPYAGDVRNDLISYGGPWKLSATWDGTEEVQMIAVAPGKPAINVQTTPGVFKTPFGTIGAVTLDFPKGTSGSPIINKKGEIIGLYGNGVLIGQGEYVSGIIQGERTEEPIPDA | ||||||
Domain | 1680-1836 | Helicase ATP-binding | ||||
Sequence: EEMLRKRKLTVLELHPGAGKTRKVLPQIIRDCIQKRLRTAVLAPTRVVACEIAEALKGMPIRYLTSAVRNEHQGNEIVDVMCHATLTQKLLTPTRVPNYQVYIMDEAHFIDPASIAARGYISTKVELGEAAAIFMTATPPGTNDPFPDSNSPILDVE | ||||||
Domain | 1847-2011 | Helicase C-terminal | ||||
Sequence: GYEWITNFTGRTVWFVPSVKSGNEIAICLQKAGKRVIQLNRKSFDTEYPKTKNNEWDFVVTTDISEMGANFGAHRVIDSRKCVKPVILEDDDRVILNGPMAITSASAAQRRGRIGRNLSQIGDEYHYGGATNEDDHDLANWTEAKILLDNIYLPNGLVAQMYQPE | ||||||
Domain | 2525-2790 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: GGGKGATLGEIWKSRLNQLTRAEFMAYRKDGIVEVDRAPARKARREGRLTGGHPVSRGSAKLRWITERGFVKPMGRVVDLGCGRGGWSYYCATLKHVQEVKGFTKGGPGHEEPQLMQSYGWNLVHMKSGVDVFHKPAESADTVLCDIGESNPSCEVEEARTARVLDMAEEWLKKGVTEFCIKVLCPYTPKIIEKLEKLQRKYGGGLVRVPLSRNSTHEMYWVSGAAGNIIHAVSMTSQVLMGRMDKQNRSGPRYEEDVNLGSGTRS | ||||||
Region | 2771-2791 | Disordered | ||||
Sequence: QNRSGPRYEEDVNLGSGTRSV | ||||||
Domain | 3054-3206 | RdRp catalytic | ||||
Sequence: GKMYADDTAGWDTRITKEDLKNEAKIAKRMEERHRKLAEAIIDLTYRHKVVKVMRPGPDGKTYMDVISREDQRGSGQVVTYALNTFTNLAVQLIRCMEAEGVVDEDDIMRVRLGRLAKAVEWLRKNGPERLSRMAVSGDDCVVKPIDDRFATA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,430
- Mass (Da)380,460
- Last updated2020-10-07 v1
- ChecksumA7BC823122D0C0E2