A0A6M5UNF8 · A0A6M5UNF8_9FLAV

Function

Catalytic activity

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site1550Charge relay system; for serine protease NS3 activity
Active site1574Charge relay system; for serine protease NS3 activity
Active site1634Charge relay system; for serine protease NS3 activity
Binding site2580S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2610S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2611S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2628S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2629S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2655S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2656S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2744S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site2964Zn2+ 1 (UniProtKB | ChEBI)
Binding site2968Zn2+ 1 (UniProtKB | ChEBI)
Binding site2973Zn2+ 1 (UniProtKB | ChEBI)
Binding site2976Zn2+ 1 (UniProtKB | ChEBI)
Binding site3241Zn2+ 2 (UniProtKB | ChEBI)
Binding site3257Zn2+ 2 (UniProtKB | ChEBI)
Binding site3376Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell endoplasmic reticulum membrane
Cellular Componenthost cell nucleus
Cellular Componentmembrane
Cellular Componentviral capsid
Cellular Componentvirion membrane
Molecular FunctionATP binding
Molecular Functiondouble-stranded RNA binding
Molecular Functionmetal ion binding
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionprotein dimerization activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionserine-type endopeptidase activity
Molecular Functionstructural molecule activity
Biological Processfusion of virus membrane with host endosome membrane
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral RNA genome replication
Biological Processvirion attachment to host cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Strain
    • COAV750
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus louisense

Accessions

  • Primary accession
    A0A6M5UNF8

Subcellular Location

Host endoplasmic reticulum membrane
; Multi-pass membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host endoplasmic reticulum membrane
; Peripheral membrane protein
Host nucleus
Secreted
Virion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane741-762Helical
Transmembrane769-789Helical
Transmembrane1139-1161Helical
Transmembrane1173-1195Helical
Transmembrane1215-1236Helical
Transmembrane1266-1283Helical
Transmembrane1295-1324Helical
Transmembrane1336-1361Helical
Transmembrane1396-1414Helical
Transmembrane1470-1493Helical
Transmembrane2171-2190Helical
Transmembrane2197-2214Helical
Transmembrane2220-2237Helical
Transmembrane2249-2266Helical
Transmembrane2308-2324Helical
Transmembrane2336-2359Helical
Transmembrane2379-2398Helical
Transmembrane2445-2461Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond291↔318
Disulfide bond348↔404
Disulfide bond362↔393
Disulfide bond380↔409
Disulfide bond478↔576
Disulfide bond593↔624

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain1369-1499Flavivirus NS2B
Domain1500-1677Peptidase S7
Domain1680-1836Helicase ATP-binding
Domain1847-2011Helicase C-terminal
Domain2525-2790MRNA cap 0-1 NS5-type MT
Region2771-2791Disordered
Domain3054-3206RdRp catalytic

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,430
  • Mass (Da)
    380,460
  • Last updated
    2020-10-07 v1
  • Checksum
    A7BC823122D0C0E2
MSKKPGKPGRNRVVNMLKRGVSRVNPLTGLKRILGSLLDGRGPVRFILAILTFFRFTALQPTEALKRRWRAVDKRTALKHLNGFKRDLGSMLDTINRRPSKKRGGTRSLLGLAALIGLASSLQLSTYQGKVLMSINKTDAQSAINIPSANGANTCIVRALDVGVMCKDDITYLCPVLSAGNDPEDIDCWCDVEEVWVHYGRCTRMGHSRRSRRSISVQHHGDSTLATKNTPWLDTVKTTKYLTKVENWVLRNPGYALVALAIGWMLGSNNTQRVVFVIMLMLIAPAYSFNCLGTSNRDFVEGASGATWIDLVLEGGSCVTVMAPEKPTLDFKVMKMDATELATVREYCYEATLDTLSTVARCPTTGEAHNTKRSDPTFVCKRDVVDRGWGNGCGLFGKGSIDTCAKFTCKNKATGKTILRENIKYEVAIFVHGSTDSTSHGNYSEQIGQNQAARFTISPQAPSYTANMGEYGTVTIDCEARSGINTEDYYVFTVKEKSWLVNRDWFHDLNLPWTSPATTDWRNRETLVEFEEPHATKQTVVALGSQEGALHTALAGAIPATVSSSTLTLQSGHLKCRAKLDKVKIKGTTYGMCDSAFTFSKNPADTGHGTVIVELQYTGSNGPCRVPISVTANLMDLTPVGRLVTVNPFISTGGANNKVMIEVEPPFGDSYIVVGRGTSQINYHWHKEGSSIGKALATTWKGAQRLAVLGDTAWDFGSIGGVFNSIGKAIHQVFGGAFRTLFGGMSWITQGLLGALLLWMGLQARDRSISLTLLAVGGILIFLATSVQADSGCAIDLQRRELKCGGGIFVYNDVEKWKSDYKYFPLTPTGLARVVQKAHADGICGIRSTSRLEHLMWENIQRELNAIFEDNEVDLSVVVQEDPKYYKRAPRRLKKLEDELEYGWKKWGKTLFMEPKLGNNTFVVDGPETKECPTASRAWNSFKVEDFGFGMVFTRLWLTIREENTTECDSAIIGTAIKGDRAVHSDLSYWIESKKNETWQLERAVMGEVKSCTWPETHTLWGDGVVESEMIIPVTLGGPKSHHNKRKGYHTQMKGPWSEGEITLDFDYCPGTTVTVTEHCGNRGASLRTTTASGKLVTDWCCRSCSLPPLRYTTKDGCWYGMEIRPMKEEEAKLVKSRVTAGVAGGMEPFQLGLLVAFIATQEVLKRRWTGKLTLASLAVCLALLIVGNITYMDLVRYLVLVGTAFAEMNTGGDVIHLALVAVFKVQPAFLAGLFLRMQWSNQENILMVIGAAFLQMAANDLKLEVLPILNAMSIAWMLIRAMKEGKVAMFALPILCALIPGMRVAGLDVIRCLLLIIGIVTLLNERRESVAKKKGGYLLAAALCQVGLCSPLIMMGGLILAHPNGKRSWPAGEVLTGVGLMCALAGGLLEFEETSMVVPFAIAGLMYITYTVSGKATEMWIEKAADITWEQNAEITGTSPRLDVDLDSHGNFKLLNDPGAPVHLFALRFVLLGLSARFYWFIPFGVLGFWLLGKHSKRGGALWDVPSPKVYPKCETKPGIYRIMTRGILGTFQAGVGVMHEGVFHTMWHATEGAVLRNGEGRLDPYAGDVRNDLISYGGPWKLSATWDGTEEVQMIAVAPGKPAINVQTTPGVFKTPFGTIGAVTLDFPKGTSGSPIINKKGEIIGLYGNGVLIGQGEYVSGIIQGERTEEPIPDAYNEEMLRKRKLTVLELHPGAGKTRKVLPQIIRDCIQKRLRTAVLAPTRVVACEIAEALKGMPIRYLTSAVRNEHQGNEIVDVMCHATLTQKLLTPTRVPNYQVYIMDEAHFIDPASIAARGYISTKVELGEAAAIFMTATPPGTNDPFPDSNSPILDVEAQVPDKAWSTGYEWITNFTGRTVWFVPSVKSGNEIAICLQKAGKRVIQLNRKSFDTEYPKTKNNEWDFVVTTDISEMGANFGAHRVIDSRKCVKPVILEDDDRVILNGPMAITSASAAQRRGRIGRNLSQIGDEYHYGGATNEDDHDLANWTEAKILLDNIYLPNGLVAQMYQPERDKVFTMDGEFRLRGEERKNFVELMRNGDLPVWLAYKVASNGHSYQDRSWCFTGQTNNTILEDNNEVEVFTKTGDRKILRPKWMDARVCCDYQALKSFKEFAAGKRSALGMMEVMGRMPNHFWEKTVAAADTLYLLGTSEANSRAHKEALAELPDSLETLLLIGMLCVMSMGTFIFLMNRKGVGKMGLGAFVITLATALLWAAEMPGTQIAGVLLIVFLLMIVLIPEPEKQRSQTDNQLAVFLICIMTLMGVVAANEMGLLEKTKSDIAKLFGSQPESVGFAARTTSWDISLDIKPATAWALYAAATMVMTPLTKHLIMTQYVNFSLTAIASQAGVLLGLTNGMPFISMDLSVPLLVLGCWNQMTLPSLAAAVMLLAVHYAFMIPGWQAEAMRAAQRRTAAGIMKNAVVDGIVATDIPDLSPATPMTEKKMGQILLIAAAVLAVLVRPGICSIKEFGVLGSAALVTLIEGTAGVVWNCTTAVGLCNLMRGGWLAGMSITWTIYKNVDKPKGKRGGGKGATLGEIWKSRLNQLTRAEFMAYRKDGIVEVDRAPARKARREGRLTGGHPVSRGSAKLRWITERGFVKPMGRVVDLGCGRGGWSYYCATLKHVQEVKGFTKGGPGHEEPQLMQSYGWNLVHMKSGVDVFHKPAESADTVLCDIGESNPSCEVEEARTARVLDMAEEWLKKGVTEFCIKVLCPYTPKIIEKLEKLQRKYGGGLVRVPLSRNSTHEMYWVSGAAGNIIHAVSMTSQVLMGRMDKQNRSGPRYEEDVNLGSGTRSVGKLTEKPDLRKVGERIRRLREEYQQTWTYDHNNPYRTWNYHGSYEVKPTGSASSMVNGVVRLLSKPWDMITNVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPLGVAQIMDVTTDWLWDFVAREKKPRICTPEEFKAKVNSHAALGAMFEEQNQWSSAREAVEDPKFWEMVDEEREAHLKGECHTCIYNMMGKREKKTGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMSRENSYGGVEGKGLQKLGYILQEISHIPGGKMYADDTAGWDTRITKEDLKNEAKIAKRMEERHRKLAEAIIDLTYRHKVVKVMRPGPDGKTYMDVISREDQRGSGQVVTYALNTFTNLAVQLIRCMEAEGVVDEDDIMRVRLGRLAKAVEWLRKNGPERLSRMAVSGDDCVVKPIDDRFATALHFLNNMSKVRKDIQEWKPSTGWHNWQEVPFCSHHFNELMLKDGRAIVVPCRSQDELIGRARISPGAGWNVKETACLSKSYAQMWLLMYFHRRDLRMMANAICSAVPVNWVPTGRTTWSIHGKGEWMTTEDMLSVWNRVWIEENEYMKDKTPLAAWSDIPYLGKREDIWCGSLIGTRTRATWAENIYAPIMQIRNLIGEEEYRDYMVAQNRFGREETHVVGGVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN233333
EMBL· GenBank· DDBJ
QJW38943.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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