A0A6M5UKZ9 · A0A6M5UKZ9_9BURK
- Proteincytochrome-c oxidase
- GeneccoN
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids479 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 copper ion per subunit, denoted as copper B.
Note: Binds 2 heme groups per subunit, denoted as high- and low-spin.
Pathway
Energy metabolism; oxidative phosphorylation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 63 | Fe (UniProtKB | ChEBI) of heme b 1; low-spin (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 210 | Cu cation B (UniProtKB | ChEBI) | |||
Binding site | 260 | Cu cation B (UniProtKB | ChEBI) | |||
Binding site | 261 | Cu cation B (UniProtKB | ChEBI) | |||
Binding site | 348 | Fe (UniProtKB | ChEBI) of heme b 2; high-spin (UniProtKB | ChEBI); axial binding residue | |||
Binding site | 350 | Fe (UniProtKB | ChEBI) of heme b 1; low-spin (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation | |
Biological Process | respiratory electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecytochrome-c oxidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Polynucleobacter
Accessions
- Primary accessionA0A6M5UKZ9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 20-44 | Helical | |||
Transmembrane | 64-84 | Helical | |||
Transmembrane | 96-120 | Helical | |||
Transmembrane | 135-153 | Helical | |||
Transmembrane | 160-180 | Helical | |||
Transmembrane | 206-228 | Helical | |||
Transmembrane | 240-257 | Helical | |||
Transmembrane | 277-297 | Helical | |||
Transmembrane | 309-329 | Helical | |||
Transmembrane | 349-368 | Helical | |||
Transmembrane | 388-416 | Helical | |||
Transmembrane | 436-459 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length479
- Mass (Da)54,146
- Last updated2020-10-07 v1
- Checksum263931EBC58C5F3E
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MK984228 EMBL· GenBank· DDBJ | QJW39076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP028942 EMBL· GenBank· DDBJ | QKM65164.1 EMBL· GenBank· DDBJ | Genomic DNA |