A0A6M4JLJ9 · A0A6M4JLJ9_BACSU

Function

function

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

Catalytic activity

  • Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.
    EC:3.1.26.11 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions.

Features

Showing features for binding site, active site.

130720406080100120140160180200220240260280300
TypeIDPosition(s)Description
Binding site63Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site65Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site67Proton acceptor
Binding site67Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site68Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site140Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site211Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site211Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site269Zn2+ 2 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function3'-tRNA processing endoribonuclease activity
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease Z
  • EC number
  • Short names
    RNase Z
  • Alternative names
    • tRNA 3 endonuclease
    • tRNase Z

Gene names

    • Name
      rnz
    • ORF names
      HIR78_14205

Organism names

Accessions

  • Primary accession
    A0A6M4JLJ9

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain18-269Metallo-beta-lactamase

Sequence similarities

Belongs to the RNase Z family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    34,023
  • Last updated
    2020-10-07 v1
  • Checksum
    6E03CA54C55D7C84
MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQHQILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIETSLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKADVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKLKELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQGDASLELQKEAVDVFPNSVAAYDFLEVNVPRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP052842
EMBL· GenBank· DDBJ
QJP89107.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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