A0A6M3ZRC3 · A0A6M3ZRC3_9BURK

Function

function

Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.

Catalytic activity

Features

Showing features for binding site.

146850100150200250300350400450
TypeIDPosition(s)Description
Binding site41-46ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctiontRNA(Ile)-lysidine synthase activity
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA(Ile)-lysidine synthase
  • EC number
  • Alternative names
    • tRNA(Ile)-2-lysyl-cytidine synthase
    • tRNA(Ile)-lysidine synthetase

Gene names

    • Name
      tilS
    • ORF names
      C798_10090

Organism names

Accessions

  • Primary accession
    A0A6M3ZRC3

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain393-465Lysidine-tRNA(Ile) synthetase C-terminal

Domain

The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

Sequence similarities

Belongs to the tRNA(Ile)-lysidine synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    468
  • Mass (Da)
    51,134
  • Last updated
    2020-10-07 v1
  • Checksum
    9429D50542A63488
MSDHPSSSPDKSLASLMQALQATLAATGFDVERDTLAVAYSGGLDSTVLLQVAAQWAQDSGGQVVALHVHHGLSANADAWWAHAQAFCAQHGLPCAAERVQLAQVADSGIEEAARLARYAALGRLCRQHGAPLLLTAHHLDDQAETVLLQLLRGSGLAGMSGMDHCNTAPGLLGDAHTLVARPFLGVTRAQLEAVARALALVWIEDESNQDPRYTRNALRHQVMPTLGQVFPGYQQRLARAAGHAQGAQELLREVAQQDLAQCRQDDHLLMPALRGLSEQRFLNLMRHWFALRGMRMPSAAWMQEMRSQLLQADVEAQLCVSHPDGEVHRYRERVFLAPRRIAPDEGASLSLRWEGQAQVRVAAFYGTLHFDPIAPDEGRPGLDAAWLRAQALLVCGRSGGERIKLGVNRPARSLKQQYQSADVPAWERPFLPLVWAGETLLFAAGIGMDCAHLVTSGERIALRWQPD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP008956
EMBL· GenBank· DDBJ
QJQ00570.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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