A0A6M3YKN7 · A0A6M3YKN7_9REOV
- ProteinNon-structural protein 5
- GeneNSP5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids210 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Plays an essential role in the viral genome replication. Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories. Participates in the selective exclusion of host proteins from stress granules (SG) and P bodies (PB). Participates also in the sequestration of these remodeled organelles in viral factories.
Cofactor
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | host cell cytoplasm | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | RNA binding | |
Biological Process | viral genome replication |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNon-structural protein 5
- Short namesNSP5
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Duplornaviricota > Resentoviricetes > Reovirales > Sedoreoviridae > Rotavirus > Rotavirus C
Accessions
- Primary accessionA0A6M3YKN7
Subcellular Location
UniProt Annotation
GO Annotation
Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.
Keywords
- Cellular component
PTM/Processing
Post-translational modification
O-glycosylated.
Keywords
- PTM
Interaction
Subunit
Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2 and NSP6.
Structure
Sequence
- Sequence statusComplete
- Length210
- Mass (Da)23,595
- Last updated2020-10-07 v1
- ChecksumCBCF251D601630A1