A0A6M3YKN7 · A0A6M3YKN7_9REOV

  • Protein
    Non-structural protein 5
  • Gene
    NSP5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Plays an essential role in the viral genome replication. Participates, together with NSP2, in the formation of viral factories (viroplasms) which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place. Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories. Participates in the selective exclusion of host proteins from stress granules (SG) and P bodies (PB). Participates also in the sequestration of these remodeled organelles in viral factories.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

121020406080100120140160180200
TypeIDPosition(s)Description
Binding site86Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componenthost cell cytoplasm
Molecular FunctionATP hydrolysis activity
Molecular Functionmagnesium ion binding
Molecular Functionnucleotide binding
Molecular FunctionRNA binding
Biological Processviral genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Non-structural protein 5
  • Short names
    NSP5
  • Alternative names
    • NS26

Gene names

    • Name
      NSP5

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • RVC/Pig-wt/BRA/BP182/2016/H1
    • RVC/Pig-wt/BRA/BP189/2016/H1
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Duplornaviricota > Resentoviricetes > Reovirales > Sedoreoviridae > Rotavirus > Rotavirus C

Accessions

  • Primary accession
    A0A6M3YKN7

Subcellular Location

Host cytoplasm
Note: Found in spherical cytoplasmic structures, called virus factories, that appear early after infection and are the site of viral replication and packaging.

Keywords

PTM/Processing

Post-translational modification

O-glycosylated.

Keywords

Interaction

Subunit

Homodimer. Interacts with VP1. Interacts with VP2. Interacts with NSP2 and NSP6.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region119-138Disordered

Sequence similarities

Belongs to the rotavirus NSP5 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    210
  • Mass (Da)
    23,595
  • Last updated
    2020-10-07 v1
  • Checksum
    CBCF251D601630A1
MSDFGINLDAICDNVKYKSSSSRTGSRVSNRSSRRMDFVDEEELSTYFNSKASVTQSDSCSNDLAIKNSIITEAVICNESEHVSADAIQEKEELIMQVDDNIMKWMMDSPDGISMNGGINFSRSKSKTNKSDFTESKSETSVSAHVSAGISSQFGMFNPIQQTVKKETISEMFEDEDSDRCVCRNCPYKDRYLKLRSKMKSVLVDIINEM

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN395904
EMBL· GenBank· DDBJ
QJI10329.1
EMBL· GenBank· DDBJ
Genomic RNA
MN395905
EMBL· GenBank· DDBJ
QJI10330.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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