A0A6M3RI55 · A0A6M3RI55_AMBTS
- ProteinCytochrome b
- GeneCYTB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids357 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 2 heme groups non-covalently.
Note: Binds 2 heme groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 73 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 87 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 172 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 186 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 191 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Arachnida > Acari > Parasitiformes > Ixodida > Ixodoidea > Ixodidae > Amblyomminae > Amblyomma
Accessions
- Primary accessionA0A6M3RI55
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-46 | Helical | ||||
Sequence: LWNFGSLLGLCLLIQILTGLFLAMNFS | ||||||
Transmembrane | 67-88 | Helical | ||||
Sequence: WLIRSVHANGASFFFIFIYIHI | ||||||
Transmembrane | 100-123 | Helical | ||||
Sequence: IKIWMSGILIIFMLMMTAFLGYIL | ||||||
Transmembrane | 135-156 | Helical | ||||
Sequence: VITNLISAIPYLGQSITLWIWG | ||||||
Transmembrane | 168-190 | Helical | ||||
Sequence: FFSLHFIFPFILMFLTLIHIMFL | ||||||
Transmembrane | 222-241 | Helical | ||||
Sequence: IMIFLIPFLMTILLFPYIMM | ||||||
Transmembrane | 261-294 | Helical | ||||
Sequence: EWYFLFAYAILRSIPSKLGGVVALIMSIMIIAFL | ||||||
Transmembrane | 315-333 | Helical | ||||
Sequence: FWMLVNTFLLLTFLGAMPI |
Keywords
- Cellular component
Interaction
Subunit
The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-199 | Cytochrome b/b6 N-terminal region profile | ||||
Sequence: MMKLMNPLINIPSPSNISYLWNFGSLLGLCLLIQILTGLFLAMNFSSDIKTAFQMISHIQRDVNFGWLIRSVHANGASFFFIFIYIHISRGIYYSSFFFIKIWMSGILIIFMLMMTAFLGYILPWGQMSFWGATVITNLISAIPYLGQSITLWIWGGFSVDNNTLIRFFSLHFIFPFILMFLTLIHIMFLHEKGSSNPM | ||||||
Domain | 200-357 | Cytochrome b/b6 C-terminal region profile | ||||
Sequence: GISMNIDKIPFHPYFSIKDLQGIMIFLIPFLMTILLFPYIMMDAENFIMANPMVTPPHIQPEWYFLFAYAILRSIPSKLGGVVALIMSIMIIAFLPFFLKNKISSLYYNNFDKFKFWMLVNTFLLLTFLGAMPIEYPYDTMSKITTSLYFFIFLLMFT |
Sequence similarities
Belongs to the cytochrome b family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length357
- Mass (Da)41,512
- Last updated2020-10-07 v1
- Checksum29D4EA9AE24CFA53