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A0A6M3B9J9 · A0A6M3B9J9_9EUCA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • AUS18
    • AUS19
    • AUS20
    • AUS21
    • AUS22
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Achelata > Palinuroidea > Palinuridae > Panulirus

Accessions

  • Primary accession
    A0A6M3B9J9

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane38-61Helical
Transmembrane82-106Helical
Transmembrane126-149Helical
Transmembrane161-188Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-208Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    208
  • Mass (Da)
    21,946
  • Last updated
    2020-10-07 v1
  • MD5 Checksum
    1CBE734148422E66A4B8BFBC46FF27F6
GAWAGMVGTSLSLIIRAELGQPGSLIGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPIMLGAPDMAFPRMNNMSFWLLPPSLTLLLASGMVESGVGTGWTVYPPLAGAVAHAGASVDLGIFSLHLAGVSSILGAVNFITTVINMRSSGMTFDRMPLFVWSVFITAILLLLSLPVLAGAITMLLTDRNLNTSFFDPVGGGDPIL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue208

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN810256
EMBL· GenBank· DDBJ
QGZ07150.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810257
EMBL· GenBank· DDBJ
QGZ07151.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810258
EMBL· GenBank· DDBJ
QGZ07152.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810259
EMBL· GenBank· DDBJ
QGZ07153.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810260
EMBL· GenBank· DDBJ
QGZ07154.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810261
EMBL· GenBank· DDBJ
QGZ07155.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810262
EMBL· GenBank· DDBJ
QGZ07156.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810263
EMBL· GenBank· DDBJ
QGZ07157.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810264
EMBL· GenBank· DDBJ
QGZ07158.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810266
EMBL· GenBank· DDBJ
QGZ07160.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810267
EMBL· GenBank· DDBJ
QGZ07161.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810268
EMBL· GenBank· DDBJ
QGZ07162.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810269
EMBL· GenBank· DDBJ
QGZ07163.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810270
EMBL· GenBank· DDBJ
QGZ07164.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810271
EMBL· GenBank· DDBJ
QGZ07165.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810272
EMBL· GenBank· DDBJ
QGZ07166.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810273
EMBL· GenBank· DDBJ
QGZ07167.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810274
EMBL· GenBank· DDBJ
QGZ07168.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810275
EMBL· GenBank· DDBJ
QGZ07169.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810276
EMBL· GenBank· DDBJ
QGZ07170.1
EMBL· GenBank· DDBJ
Genomic DNA
MN810277
EMBL· GenBank· DDBJ
QGZ07171.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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