A0A6M3B9J9 · A0A6M3B9J9_9EUCA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids208 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Crustacea > Multicrustacea > Malacostraca > Eumalacostraca > Eucarida > Decapoda > Pleocyemata > Achelata > Palinuroidea > Palinuridae > Panulirus
Accessions
- Primary accessionA0A6M3B9J9
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 38-61 | Helical | |||
Transmembrane | 82-106 | Helical | |||
Transmembrane | 126-149 | Helical | |||
Transmembrane | 161-188 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length208
- Mass (Da)21,946
- Last updated2020-10-07 v1
- MD5 Checksum1CBE734148422E66A4B8BFBC46FF27F6
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 208 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MN810256 EMBL· GenBank· DDBJ | QGZ07150.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810257 EMBL· GenBank· DDBJ | QGZ07151.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810258 EMBL· GenBank· DDBJ | QGZ07152.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810259 EMBL· GenBank· DDBJ | QGZ07153.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810260 EMBL· GenBank· DDBJ | QGZ07154.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810261 EMBL· GenBank· DDBJ | QGZ07155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810262 EMBL· GenBank· DDBJ | QGZ07156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810263 EMBL· GenBank· DDBJ | QGZ07157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810264 EMBL· GenBank· DDBJ | QGZ07158.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810266 EMBL· GenBank· DDBJ | QGZ07160.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810267 EMBL· GenBank· DDBJ | QGZ07161.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810268 EMBL· GenBank· DDBJ | QGZ07162.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810269 EMBL· GenBank· DDBJ | QGZ07163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810270 EMBL· GenBank· DDBJ | QGZ07164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810271 EMBL· GenBank· DDBJ | QGZ07165.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810272 EMBL· GenBank· DDBJ | QGZ07166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810273 EMBL· GenBank· DDBJ | QGZ07167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810274 EMBL· GenBank· DDBJ | QGZ07168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810275 EMBL· GenBank· DDBJ | QGZ07169.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810276 EMBL· GenBank· DDBJ | QGZ07170.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN810277 EMBL· GenBank· DDBJ | QGZ07171.1 EMBL· GenBank· DDBJ | Genomic DNA |