A0A6M2R210 · A0A6M2R210_9NEOP
- ProteinCytochrome c oxidase subunit 2
- GeneCOII
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids239 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Note: Binds a copper A center.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | copper ion binding | |
Molecular Function | cytochrome-c oxidase activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 2
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Geometroidea > Geometridae > Ennominae > Biston
Accessions
- Primary accessionA0A6M2R210
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 34-57 | Helical | |||
Transmembrane | 69-93 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-97 | Cytochrome oxidase subunit II transmembrane region profile | |||
Domain | 98-231 | Cytochrome oxidase subunit II copper A binding | |||
Sequence similarities
Belongs to the cytochrome c oxidase subunit 2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length239
- Mass (Da)27,920
- Last updated2020-10-07 v1
- ChecksumEFF589F5CD7FAC11
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 239 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MK067371 EMBL· GenBank· DDBJ | QAT93060.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067372 EMBL· GenBank· DDBJ | QAT93061.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067373 EMBL· GenBank· DDBJ | QAT93062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067374 EMBL· GenBank· DDBJ | QAT93063.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067375 EMBL· GenBank· DDBJ | QAT93064.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067376 EMBL· GenBank· DDBJ | QAT93065.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067377 EMBL· GenBank· DDBJ | QAT93066.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067378 EMBL· GenBank· DDBJ | QAT93067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067379 EMBL· GenBank· DDBJ | QAT93068.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067380 EMBL· GenBank· DDBJ | QAT93069.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067381 EMBL· GenBank· DDBJ | QAT93070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067382 EMBL· GenBank· DDBJ | QAT93071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067383 EMBL· GenBank· DDBJ | QAT93072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067384 EMBL· GenBank· DDBJ | QAT93073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067385 EMBL· GenBank· DDBJ | QAT93074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067386 EMBL· GenBank· DDBJ | QAT93075.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067387 EMBL· GenBank· DDBJ | QAT93076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067388 EMBL· GenBank· DDBJ | QAT93077.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067389 EMBL· GenBank· DDBJ | QAT93078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067390 EMBL· GenBank· DDBJ | QAT93079.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067391 EMBL· GenBank· DDBJ | QAT93080.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067392 EMBL· GenBank· DDBJ | QAT93081.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067393 EMBL· GenBank· DDBJ | QAT93082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067394 EMBL· GenBank· DDBJ | QAT93083.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067395 EMBL· GenBank· DDBJ | QAT93084.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067396 EMBL· GenBank· DDBJ | QAT93085.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067397 EMBL· GenBank· DDBJ | QAT93086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067398 EMBL· GenBank· DDBJ | QAT93087.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067399 EMBL· GenBank· DDBJ | QAT93088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067403 EMBL· GenBank· DDBJ | QAT93092.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067404 EMBL· GenBank· DDBJ | QAT93093.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067406 EMBL· GenBank· DDBJ | QAT93095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067407 EMBL· GenBank· DDBJ | QAT93096.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067408 EMBL· GenBank· DDBJ | QAT93097.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067409 EMBL· GenBank· DDBJ | QAT93098.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067410 EMBL· GenBank· DDBJ | QAT93099.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067411 EMBL· GenBank· DDBJ | QAT93100.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067412 EMBL· GenBank· DDBJ | QAT93101.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067413 EMBL· GenBank· DDBJ | QAT93102.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067414 EMBL· GenBank· DDBJ | QAT93103.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067415 EMBL· GenBank· DDBJ | QAT93104.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067416 EMBL· GenBank· DDBJ | QAT93105.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067418 EMBL· GenBank· DDBJ | QAT93107.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK067419 EMBL· GenBank· DDBJ | QAT93108.1 EMBL· GenBank· DDBJ | Genomic DNA |