A0A6M2R210 · A0A6M2R210_9NEOP

  • Protein
    Cytochrome c oxidase subunit 2
  • Gene
    COII
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper A center.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncopper ion binding
Molecular Functioncytochrome-c oxidase activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 2

Gene names

    • Name
      COII

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 1109
    • 1116
    • 1117
    • 1119
    • 1122
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Geometroidea > Geometridae > Ennominae > Biston

Accessions

  • Primary accession
    A0A6M2R210

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane34-57Helical
Transmembrane69-93Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-97Cytochrome oxidase subunit II transmembrane region profile
Domain98-231Cytochrome oxidase subunit II copper A binding

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    239
  • Mass (Da)
    27,920
  • Last updated
    2020-10-07 v1
  • Checksum
    EFF589F5CD7FAC11
HILFLEMATWSNFNLQNGASPLMEQIIFFHDHTLIILIMITILVSYLMINLLFNKYINRFLLEGQMIELIWTILPAITLIFIALPSLRLLYLLDELNNPLITLKSIGHQWYWSYEYSDFHNIEFDSYMIPSNESNLNNFRLLDVDNRIILPMNNQIRILVTATDVIHSWTIPSLGVKVDANPGRLNQTNFYINRPGIYYGQCSEICGANHSFMPIVIESISIKNFINWINNYSSLDDRK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue239

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK067371
EMBL· GenBank· DDBJ
QAT93060.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067372
EMBL· GenBank· DDBJ
QAT93061.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067373
EMBL· GenBank· DDBJ
QAT93062.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067374
EMBL· GenBank· DDBJ
QAT93063.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067375
EMBL· GenBank· DDBJ
QAT93064.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067376
EMBL· GenBank· DDBJ
QAT93065.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067377
EMBL· GenBank· DDBJ
QAT93066.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067378
EMBL· GenBank· DDBJ
QAT93067.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067379
EMBL· GenBank· DDBJ
QAT93068.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067380
EMBL· GenBank· DDBJ
QAT93069.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067381
EMBL· GenBank· DDBJ
QAT93070.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067382
EMBL· GenBank· DDBJ
QAT93071.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067383
EMBL· GenBank· DDBJ
QAT93072.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067384
EMBL· GenBank· DDBJ
QAT93073.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067385
EMBL· GenBank· DDBJ
QAT93074.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067386
EMBL· GenBank· DDBJ
QAT93075.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067387
EMBL· GenBank· DDBJ
QAT93076.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067388
EMBL· GenBank· DDBJ
QAT93077.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067389
EMBL· GenBank· DDBJ
QAT93078.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067390
EMBL· GenBank· DDBJ
QAT93079.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067391
EMBL· GenBank· DDBJ
QAT93080.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067392
EMBL· GenBank· DDBJ
QAT93081.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067393
EMBL· GenBank· DDBJ
QAT93082.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067394
EMBL· GenBank· DDBJ
QAT93083.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067395
EMBL· GenBank· DDBJ
QAT93084.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067396
EMBL· GenBank· DDBJ
QAT93085.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067397
EMBL· GenBank· DDBJ
QAT93086.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067398
EMBL· GenBank· DDBJ
QAT93087.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067399
EMBL· GenBank· DDBJ
QAT93088.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067403
EMBL· GenBank· DDBJ
QAT93092.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067404
EMBL· GenBank· DDBJ
QAT93093.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067406
EMBL· GenBank· DDBJ
QAT93095.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067407
EMBL· GenBank· DDBJ
QAT93096.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067408
EMBL· GenBank· DDBJ
QAT93097.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067409
EMBL· GenBank· DDBJ
QAT93098.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067410
EMBL· GenBank· DDBJ
QAT93099.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067411
EMBL· GenBank· DDBJ
QAT93100.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067412
EMBL· GenBank· DDBJ
QAT93101.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067413
EMBL· GenBank· DDBJ
QAT93102.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067414
EMBL· GenBank· DDBJ
QAT93103.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067415
EMBL· GenBank· DDBJ
QAT93104.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067416
EMBL· GenBank· DDBJ
QAT93105.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067418
EMBL· GenBank· DDBJ
QAT93107.1
EMBL· GenBank· DDBJ
Genomic DNA
MK067419
EMBL· GenBank· DDBJ
QAT93108.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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