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A0A6L8MBH1 · A0A6L8MBH1_ACIBA

  • Protein
    Imidazole glycerol phosphate synthase subunit HisH
  • Gene
    hisH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site80Nucleophile
Active site185
Active site187

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutaminase activity
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionlyase activity
Biological Processglutamine metabolic process
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase subunit HisH
  • EC number
  • Alternative names
    • IGP synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)
    • IGP synthase subunit HisH
    • ImGP synthase subunit HisH
      (IGPS subunit HisH
      )

Gene names

    • Name
      hisH
    • ORF names
      ABR2091_3434
      , GSE42_18795
      , H0529_17630
      , JHZ39_001382

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • R2091
    • DMS06669
    • AC1633
    • 2018HL-00813
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex

Accessions

  • Primary accession
    A0A6L8MBH1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterodimer of HisH and HisF.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-201Glutamine amidotransferase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    205
  • Mass (Da)
    22,769
  • Last updated
    2020-10-07 v1
  • MD5 Checksum
    8CF44840533E85495396E58188D3D2D3
MTRIALLDYGMGNLHSAAKALEYVGATVDVTNDPKLIAQADKIVFPGVGAMRDCMQGMREAGIDEVVRKAAFNKPVLAICVGMQALLQSSEENGGVDALGIFDGVVKHFPQMEGLKVPHMGWNQVHQMDPSHPMWNSIEQDARFYFVHSYYVEPKDENLVAATCEYGVNFCTAIHKDNLFATQFHPEKSHTAGLQLLKNFVEWNI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN997846
EMBL· GenBank· DDBJ
CUW36793.1
EMBL· GenBank· DDBJ
Genomic DNA
AAYLMQ010000012
EMBL· GenBank· DDBJ
EGY2377027.1
EMBL· GenBank· DDBJ
Genomic DNA
WWCH01000001
EMBL· GenBank· DDBJ
MYM79960.1
EMBL· GenBank· DDBJ
Genomic DNA
CP059300
EMBL· GenBank· DDBJ
QOJ59487.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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