A0A6L7GVQ6 · A0A6L7GVQ6_9ACTN

  • Protein
    6-phosphogluconate dehydrogenase, decarboxylating
  • Gene
    gndA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site23-28NADP+ (UniProtKB | ChEBI)
Binding site46-48NADP+ (UniProtKB | ChEBI)
Binding site88-90NADP+ (UniProtKB | ChEBI)
Binding site116NADP+ (UniProtKB | ChEBI)
Binding site116substrate; ligand shared between dimeric partners; in other chain
Binding site142-144substrate; ligand shared between dimeric partners; in other chain
Active site196Proton acceptor
Binding site199-200substrate; ligand shared between dimeric partners; in other chain
Active site203Proton donor
Binding site204substrate; ligand shared between dimeric partners; in other chain
Binding site274substrate; ligand shared between dimeric partners; in other chain
Binding site301substrate; ligand shared between dimeric partners; in other chain
Binding site459substrate; ligand shared between dimeric partners
Binding site465substrate; ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate catabolic process
Biological Processpentose-phosphate shunt, oxidative branch

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Gene names

    • Name
      gndA
    • ORF names
      GIY30_22280

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HNM0687
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia

Accessions

  • Primary accession
    A0A6L7GVQ6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain192-4816-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    489
  • Mass (Da)
    52,085
  • Last updated
    2020-10-07 v1
  • Checksum
    A883D199C5423A3B
MTTSAATDSDPTDATKAQIGVTGLAVMGSNIARNFAHKGYTVALHNRSIAKTDALIEQHGSEGSFIRTETVEEFIAALERPRRVLIMVKAGAATDAVIEELAAAMEPGDIIIDGGNALYTDTIRRERALAERGLHFVGAGISGGEEGALNGPSIMPGGPAESYKSLGPLLESISAHVDGEPCCTHIGPDGSGHFVKMVHNGIEYADMQLIGEAYDLMRKALDMPVADIANVFREWNSGDLDSYLVEITAEVLSQVDAETGKPLVDVIVDAAGQKGTGRWTVKSALDLGIPTTGIAEAVFARALSSATDQRKQAQGLESGTLSAAPTDTTTFVDDINKALYASKVVAYAQGFDQIAAGSAEYGWDVAPGDLATIWRGGCIIRAKFLNRIRDAYAENPELPSLLLAPYFRTALEDAVDSWRRVVATATTMGIPVPAFASSLSYYDALRSERLPAALTQGLRDFFGAHTYQRIDKPGTFHTLWSGDRTEVTA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WMBR01000008
EMBL· GenBank· DDBJ
MXP24069.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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