A0A6L7GVQ6 · A0A6L7GVQ6_9ACTN
- Protein6-phosphogluconate dehydrogenase, decarboxylating
- GenegndA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids489 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalytic activity
- 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 23-28 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 46-48 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 88-90 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 116 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 116 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 142-144 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 196 | Proton acceptor | |||
Binding site | 199-200 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 203 | Proton donor | |||
Binding site | 204 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 274 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 301 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 459 | substrate; ligand shared between dimeric partners | |||
Binding site | 465 | substrate; ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | phosphogluconate dehydrogenase (decarboxylating) activity | |
Biological Process | D-gluconate catabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-phosphogluconate dehydrogenase, decarboxylating
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia
Accessions
- Primary accessionA0A6L7GVQ6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length489
- Mass (Da)52,085
- Last updated2020-10-07 v1
- ChecksumA883D199C5423A3B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
WMBR01000008 EMBL· GenBank· DDBJ | MXP24069.1 EMBL· GenBank· DDBJ | Genomic DNA |