A0A6L7GMA9 · A0A6L7GMA9_9ACTN

  • Protein
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • Gene
    panB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site68Mg2+ (UniProtKB | ChEBI)
Binding site68-693-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site1073-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site107Mg2+ (UniProtKB | ChEBI)
Binding site1373-methyl-2-oxobutanoate (UniProtKB | ChEBI)
Binding site139Mg2+ (UniProtKB | ChEBI)
Active site205Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionmethyltransferase activity
Biological Processmethylation
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-methyl-2-oxobutanoate hydroxymethyltransferase
  • EC number
  • Alternative names
    • Ketopantoate hydroxymethyltransferase
      (KPHMT
      )

Gene names

    • Name
      panB
    • ORF names
      GIY30_06750

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HNM0687
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia

Accessions

  • Primary accession
    A0A6L7GMA9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodecamer; pentamer of dimers.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-27Disordered

Sequence similarities

Belongs to the PanB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    287
  • Mass (Da)
    30,082
  • Last updated
    2020-10-07 v1
  • Checksum
    F312876707346E43
MSESSVYGATGPVAGDSSASAPRRRPTRVHHLAQMKADGEKWSMLTCYDYSTARIFDAAEIPVLLVGDSAANVVLGYDTTIPVTVDELIPLIRAVVRGAPHALVVADLPFGSYEAGPQQALESAVKVFKETGAHAIKLEGGERVADQVAALTAAGIPVMAHIGFTPQSVNGLGGYRVQGRGDAGDQLVADAIAVQEAGAFAVVMEMVPADLAGQITRKLTIPTVGIGAGNETDAQVLVWQDMAGLTHGKTAKFVKRFADIGSELRSAAEQYADEVRRGAFPAPEHSY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WMBR01000001
EMBL· GenBank· DDBJ
MXP21050.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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