A0A6L5EEI6 · A0A6L5EEI6_9ENTR

  • Protein
    Quinate/shikimate dehydrogenase
  • Gene
    ydiB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site47substrate
Binding site83substrate
Binding site108-111NAD+ (UniProtKB | ChEBI)
Binding site181NAD+ (UniProtKB | ChEBI)
Binding site208-211NAD+ (UniProtKB | ChEBI)
Binding site231NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionquinate 3-dehydrogenase (NAD+) activity
Molecular Functionquinate 3-dehydrogenase (NADP+) activity
Molecular Functionshikimate 3-dehydrogenase (NAD+) activity
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Quinate/shikimate dehydrogenase
  • EC number
  • Alternative names
    • NAD-dependent shikimate 5-dehydrogenase

Gene names

    • Name
      ydiB
    • ORF names
      GBB84_23575

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NMI7905_11
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Citrobacter

Accessions

  • Primary accession
    A0A6L5EEI6

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-70Shikimate dehydrogenase substrate binding N-terminal
Domain231-260SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    264
  • Mass (Da)
    28,589
  • Last updated
    2020-10-07 v1
  • Checksum
    9D5B8012A4C6CD48
MQNKALEKAGLPFTYMAFEVDNSTFAGAIEGLKALKMRGTGVSMPNKQLACEFVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIRGKTMVLLGAGGASTAIGAQAAIEGIKEIKLFNRNDEFFQKALDFAKRVNENTDCVVTVTDLADQQAFADALATADILTNGTKVGMKPLDNESIVSDVSLLRPELLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFKLWTGKDFPLEYVKQVMGFAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WHIY01000020
EMBL· GenBank· DDBJ
MPQ53874.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp