A0A6L3VFX8 · A0A6L3VFX8_9ACTN

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13substrate
Active site68Proton acceptor
Binding site68Mg2+ (UniProtKB | ChEBI)
Binding site69substrate
Binding site161-164substrate
Binding site184substrate
Binding site189-190substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      F9B16_48365

Organism names

  • Taxonomic identifier
  • Strain
    • CYP1-1B
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Streptosporangiales > Thermomonosporaceae > Actinomadura

Accessions

  • Primary accession
    A0A6L3VFX8

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    211
  • Mass (Da)
    21,725
  • Last updated
    2020-10-07 v1
  • Checksum
    1632797951181CDF
MTRIVLATRNAGKIAELERILGGIDVAGLAEFPDAPEVPETELTFEGNALLKARAIAAHTGLPAVADDSGLCVDALNGMPGVLSARWSGRFGDATGDKDAANLRLVLDQLGDVADGLRGAAFVCAAALVVPAHGDRGAVEHTVEGRMRGTIVRAPRGTGGFGYDPVFLPDGETRTTAEMAPEEKDAISHRGKAFRALAGLLPDALAAAGHP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WBMR01000358
EMBL· GenBank· DDBJ
KAB2357760.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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