A0A6L2R6K5 · A0A6L2R6K5_9BACT

Function

function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site27-28D-ribulose 5-phosphate (UniProtKB | ChEBI)
Binding site28Mg2+ 1 (UniProtKB | ChEBI)
Binding site28Mg2+ 2 (UniProtKB | ChEBI)
Binding site32D-ribulose 5-phosphate (UniProtKB | ChEBI)
Site126Essential for DHBP synthase activity
Binding site164D-ribulose 5-phosphate (UniProtKB | ChEBI)
Site164Essential for DHBP synthase activity
Binding site253-257GTP (UniProtKB | ChEBI)
Binding site258Zn2+ (UniProtKB | ChEBI); catalytic
Binding site269Zn2+ (UniProtKB | ChEBI); catalytic
Binding site271Zn2+ (UniProtKB | ChEBI); catalytic
Binding site274GTP (UniProtKB | ChEBI)
Binding site296-298GTP (UniProtKB | ChEBI)
Binding site318GTP (UniProtKB | ChEBI)
Active site330Proton acceptor; for GTP cyclohydrolase activity
Active site332Nucleophile; for GTP cyclohydrolase activity
Binding site353GTP (UniProtKB | ChEBI)
Binding site358GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Riboflavin biosynthesis protein RibBA

Including 2 domains:

  • Recommended name
    3,4-dihydroxy-2-butanone 4-phosphate synthase
  • EC number
  • Short names
    DHBP synthase
  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribBA
    • ORF names
      ZNDK_0865

Organism names

  • Taxonomic identifier
  • Strain
    • ZnDsv-02
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Desulfovibrionia > Desulfovibrionales > Desulfovibrionaceae > Desulfovibrio

Accessions

  • Primary accession
    A0A6L2R6K5

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-201DHBP synthase
Region202-404GTP cyclohydrolase II
Domain211-374GTP cyclohydrolase II

Sequence similarities

In the C-terminal section; belongs to the GTP cyclohydrolase II family.
In the N-terminal section; belongs to the DHBP synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    404
  • Mass (Da)
    44,035
  • Last updated
    2020-10-07 v1
  • Checksum
    DD1AF45A044F77A1
MPMCSVEQALADIRQGKMIILVDDEDRENEGDLMMAAEHVSAEAINFMAKYGRGLICLPMAPEMIDRLQLPLMTQRNGSRFGTNFTVSIEAREGIATGISAQDRAATILAAVAANAKPEDIVTPGHVFPLRARTDGVLARAGQTEGGVDMARLAGLKPAAVICEIMNDDGTMARMPELEKFSLDHGINIATVKDIIRYRLDRGQVSVRSAANARLPSLYGDFMVHAYESEVESGTHLALVKGDISGAEPVLARVHSQCLTGDALGSLRCDCGGQLGAAMRQIEREGRGVLLYMRQEGRGIGLANKIRAYALQDQGYDTVEANRKLGFPDDLRDYGTGAQILVNLGIRKVRLLTNNPKKVVGLAGYGIEIVERVPIEIEACQENEQYLRTKKEKMAHMLTSVRCH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BLLL01000009
EMBL· GenBank· DDBJ
GFH63094.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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