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A0A6J7U7I4 · A0A6J7U7I4_9ZZZZ

  • Protein
    Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionlysine-tRNA ligase activity
Molecular Functionphosphatidylglycerol lysyltransferase activity
Molecular FunctiontRNA binding
Biological Processlipid metabolic process
Biological Processlysyl-tRNA aminoacylation
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX
  • EC number

Gene names

    • ORF names
      UFOPK4354_00225

Organism names

Accessions

  • Primary accession
    A0A6J7U7I4

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane531-553Helical
Transmembrane565-584Helical
Transmembrane596-612Helical
Transmembrane618-634Helical
Transmembrane654-672Helical
Transmembrane709-730Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain168-486Aminoacyl-transfer RNA synthetases class-II family profile

Sequence similarities

In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
In the N-terminal section; belongs to the LPG synthetase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,092
  • Mass (Da)
    119,626
  • Last updated
    2020-10-07 v1
  • MD5 Checksum
    CB4CE65AFBBCCE14DB2E2AFF69870ACE
MGELQHARTSWRAARLAELEGMRCAGVDPYPGRFDATTSISQLRAQFVDLPASAETEERVSCTGRVVLLRDHGGIWFVTLESGGAKLQLMCDSRPRVEPPRRGDLIGVTGLIVASRTGELSVRVQEFELLSASLVAPGDKRGRPRSVEHRSRYREADLMENLQSRKVFTMRSEAISGIRVALEARGFLEVETPVFAADAGGATARPFVTRHNALGQDLMMRIAPELFLKRLVIGGMDRVFELGRVFRNEGMSAKHNPEFTMLEVYQAYADYIDMMELVQHVVVEAALASLGSTTVRIPSGQQVDLALPWRRASMSDLVFEHTGERIEARMELGQSRAALGRLGLGFDEVWGSGRCLVAVFEDRVEANLISPTIVTGHPVETSPLARHCRTDPSLTERFEVIVGGMELANAYSELNDPVEQRERFMSERSRAQAAGEETLLSSSLDQRYVEALERGLPPTGGLGIGIDRLVMLLTNSSSIRDVILFPTMRSPHAETPAANGRSDLVPTAPLPTATAPGAQVAAVRLSGLVRVVAMLTSLVGVLTMLSAVPAISARTLLLDELISPLPLVLDTAVLSVGFGSCMVLLSGQLLRGKRRAWNLALVLFVLSAGFSIARGGEAVALTTSLSMIVILLLTRSEFTGLADPPSLVRVARMIPRFLLLVYVYGLIALWAQQGTLSPSINLSDSFWAVTVGLVGGEQPYEYSGRFARLFPVSLEVLGALGLLLLLWLLLRPAVRGRVGEGRERAAAMVEQFGWDTLAPFACRDDKSYFFSSDGLAMVAYGYLGGFALVSGDPIGEDASIPLVVDEFILHCQHHGWQPAFLAAREVDVPLYAERGFRSFYLGDEAILDCRTFSLEAEGMAPVRQAVRRAEKAHRFELMAEESASPALVSALNQISLLWRKGEDERGYTMSMSSDVSAVGSNRLLAVAWQINQDGSEEPAGFLRLVPTSAVTDRFAPGQTLDLMRRRPDAANGLTEYLIAHTVQDLRELGVVRLSLNFAAFGRLLDNDVQLTRGNRFLRKLVDLLNPYYQIRALRDFNEKFQPTWLPRVLIYADPADLPKVGLRYAWLEGIVSVPIIGRLLSGPTEVVEGEAT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAFBQW010000013
EMBL· GenBank· DDBJ
CAB5061362.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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