A0A6J6PLE1 · A0A6J6PLE1_9ZZZZ

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      UFOPK2593_00599
      , UFOPK4234_00770

Organism names

Accessions

  • Primary accession
    A0A6J6PLE1

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane23-40Helical
Transmembrane60-84Helical
Transmembrane96-115Helical
Transmembrane121-142Helical
Transmembrane154-173Helical
Transmembrane179-200Helical
Transmembrane270-291Helical
Transmembrane300-318Helical
Transmembrane324-346Helical
Transmembrane367-386Helical
Transmembrane392-412Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-420Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    424
  • Mass (Da)
    46,429
  • Last updated
    2020-10-07 v1
  • Checksum
    E46C1531E5869593
MEPSGNPEIRSVTPIVERVGGKAWLYWGVAALAYLVAVHQRSSFGVASLDAAHRYHVGPALLSLFAVVQIVAYSLAQIPVGVALDHFGPRRMITTGAFVMGVGQLLLAFTNVYPLALAGRIIVGLGDAMTFISVLRVTTSWFPPSRNAMMTQIIGLLGWIGQLLSAIPFAYVLRHQSWTFSFSLLTVTSTVVGTFSYLIVRDRNPELLLNSWPTRKALINRVKITWAHPATKIGFWSHWSSPFSANMFSLIWGVPFLVKAEGFSKSQATTSLTSIVFFGALAGIALGYLIGHFPKHLDRISYSVCTLIAAFWTLVLLWPGQAPYSLLIALMGIISIGGPASLTGFAHARKHIPLENMGTADGIINAAGFYSTLLAMLSVGIVLQIFGNYSLTSFRVAFLTLYPIWIIGFIKIRKYHNQLERHTS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAEZXW010000027
EMBL· GenBank· DDBJ
CAB4700360.1
EMBL· GenBank· DDBJ
Genomic DNA
CAFBQA010000035
EMBL· GenBank· DDBJ
CAB5038272.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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