A0A6J4KC59 · A0A6J4KC59_9BACT

Function

function

Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site86Nucleophile
Active site203
Active site205

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionglutaminase activity
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Molecular Functiontransferase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase subunit PurQ
  • EC number
  • Short names
    FGAM synthase
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase subunit I
      (FGAR amidotransferase I
      ; FGAR-AT I
      )
    • Glutaminase PurQ
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)
    • Phosphoribosylformylglycinamidine synthase subunit I

Gene names

    • Name
      purQ
    • ORF names
      AVDCRST_MAG68-670

Organism names

Accessions

  • Primary accession
    A0A6J4KC59

Subcellular Location

Keywords

Interaction

Subunit

Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.

Family & Domains

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    231
  • Mass (Da)
    24,596
  • Last updated
    2020-10-07 v1
  • Checksum
    EECDC6CD45CB1763
MKIGVVTFPGSNCDYDCYKAVQEQMEAEAVYLWHGDHDLQGVDAVFLPGGFSYGDYLRAGAIAAQSPILREVRAFAEAGGPVAGICNGFQILCEAALLPGALMRNRSLKFRSRSVHLRVERTDTPFTSGYAAGQVLHVPIAHGEGCYFADEATLDRVEGQGLVAFRYSAPDGTIDAEANPNGSARNIAGVVNERGNVLGMMPHPERAVDALLGSTDGLGLFRSLAAHLARA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CADCTW010000031
EMBL· GenBank· DDBJ
CAA9301889.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp