A0A6J4KAE5 · A0A6J4KAE5_9BACT

Function

function

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site10NADPH (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site13NADPH (UniProtKB | ChEBI)
Binding site36NADPH (UniProtKB | ChEBI)
Binding site117NADPH (UniProtKB | ChEBI)
Binding site1181-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site119NADPH (UniProtKB | ChEBI)
Binding site143Mn2+ (UniProtKB | ChEBI)
Binding site1441-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1451-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site145Mn2+ (UniProtKB | ChEBI)
Binding site1691-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1921-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site198NADPH (UniProtKB | ChEBI)
Binding site2051-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2101-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2111-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2141-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site214Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Molecular Functionisomerase activity
Molecular Functionmanganese ion binding
Molecular FunctionNADPH binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • EC number
  • Short names
    DXP reductoisomerase
  • Alternative names
    • 1-deoxyxylulose-5-phosphate reductoisomerase
    • 2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

    • Name
      dxr
    • ORF names
      AVDCRST_MAG68-340

Organism names

Accessions

  • Primary accession
    A0A6J4KAE5

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-1251-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Domain139-2221-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
Domain254-370DXP reductoisomerase C-terminal

Sequence similarities

Belongs to the DXR family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    383
  • Mass (Da)
    39,684
  • Last updated
    2020-10-07 v1
  • Checksum
    97C0FAE63A6BE70B
MKGVSILGATGSIGRSALAVLDQHPDRFRAVALTAGTRGEALGRLAERYGPALAVVAEGPVPAGACGGTEWRTGREALLAAATHPDADVVLNALVGAAGLEPTLAALRAGKRVALANKESLVCAGPLVMEAAREGGGELVPVDSEHSAILQCLAGTSADAVRRLVLTASGGPFREWTAAMLATATPADALRHPTWDMGSKVTIDSATLANKALEVIEAHFLFGIPYERIEAVVHPQSIIHSMVEMVDGSVLAQMGFPTMELPVLYALSYPERLPYECRRFDPVAAGALTFEPVDGERFPAFGLGVAAGREGGTAPAVFNAANEVAVAHFLGGALGFPGIAEAVGDTLGQWRGGAADSLAAVLEADAWARRTTETFVRNYLPCC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CADCTW010000022
EMBL· GenBank· DDBJ
CAA9300063.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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